ArticleJournal of proteome research2008
Amazing stability of phosphate-quaternary amine interactions.
Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Synthesis and characterization of amine-functionalized graphene as a nitric oxide-generating coating for vascular stents.Applied physics reviews · 2024Article
- Directing cellular responses in a nanocomposite 3D matrix for tissue regeneration with nanoparticle-mediated drug delivery.Materials today. Bio · 2023Article
- Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells.Gels (Basel, Switzerland) · 2022Article
- Dihydropyridine Lactam Analogs Targeting BET Bromodomains.ChemMedChem · 2022Article
- Ion/ion Charge Inversion/Attachment in Conjunction with Dipolar DC Collisional Activation as a Selective Screen for Sulfo- and Phosphopeptides.International journal of mass spectrometry · 2019Article
- Interactions of Protonated Guanidine and Guanidine Derivatives with Multiply Deprotonated RNA Probed by Electrospray Ionization and Collisionally Activated Dissociation.ChemistryOpen · 2017Article
- Gas-phase intermolecular phosphate transfer within a phosphohistidine phosphopeptide dimer.International journal of mass spectrometry · 2014Article
- Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.Reviews in the neurosciences · 2014Review
- Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- MALDI/post ionization-ion mobility mass spectrometry of noncovalent complexes of dopamine receptors' epitopes.Journal of proteome research · 2013Article
- Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor.Journal of proteome research · 2012Article
- Competition between covalent and noncovalent bond cleavages in dissociation of phosphopeptide-amine complexes.Physical chemistry chemical physics : PCCP · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously used MALDI mass spectrometry to highlight ammonium- or guanidinium-aromatic interactions via cation-pi bonding and ammonium- or guanidinium-phosphate interactions through salt bridge formation. In the present work, the gas-phase stability and dissociation pathways of the interaction between phosphorylated peptides and compounds containing quaternary amines are demonstrated using electrospray ionization mass spectrometry. The presence of one quaternary amine in a compound is enough to form a noncovalent complex with a phosphorylated residue. However, if two quaternary amines are present in one molecule, the electrostatic interactions of the quaternary amines with the phosphate results in a "covalent-like" stability, and these bonds can withstand fragmentation by collision-induced dissociation at energies similar to those that fragment covalent bonds. Such interactions are important in accounting for physiological, pathophysiological, and pharmacological effects of many therapeutic compounds and small molecules containing quaternary amines or phosphates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.