ArticleNature clinical practice. Cardiovascular medicine2008
Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction.
Article in Nature clinical practice. Cardiovascular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.European journal of nutrition · 2020Trial
- Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).Cardiovascular diabetology · 2011Trial
- Article
- Differential phenotype and behavior in culture of CD34 positive cells from peripheral blood and adipose tissue.Heliyon · 2021Review
- Transplantation of CD34+ cells for myocardial ischemia.World journal of transplantation · 2021Review
- Endogenous PCSK9 may influence circulating CD45Scientific reports · 2021Observational
- Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets.PloS one · 2021Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Article
- Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges.Stem cells translational medicine · 2016Review
- Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2016Review
- Analysis of Various Subsets of Circulating Mononuclear Cells in Asymptomatic Coronary Artery Disease.Journal of clinical medicine · 2013Article
- Inflammatory and injury signals released from the post-stenotic human kidney.European heart journal · 2013Article
- Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns.BMC pediatrics · 2012Article
- Circulating angiogenic cell populations, vascular function, and arterial stiffness.Atherosclerosis · 2012Article
- Effect of enhanced external counterpulsation on circulating CD34+ progenitor cell subsets.International journal of cardiology · 2011Article
- Phenotyping patient-derived cells for translational studies in cardiovascular disease.Circulation · 2011Review
- Regulation of circulating progenitor cells in left ventricular dysfunction.Circulation. Heart failure · 2010Article
- Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.Experimental eye research · 2010Article
- Identification and validation of genes affecting aortic lesions in mice.The Journal of clinical investigation · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundEndothelial dysfunction is an early manifestation of atherosclerotic disease. Circulating cells that express CD34, including endothelial and hematopoietic progenitor cells, might play a part in the development and progression of atherosclerosis. The aim of this study was to evaluate the association between coronary endothelial dysfunction and concentrations of circulating CD34+ cell subsets.
methodsIntracoronary acetylcholine challenge was used to test for coronary endothelial dysfunction in 57 consecutive patients scheduled to undergo diagnostic coronary angiography and with no signs of substantial obstructive lesions. Mononuclear cells were extracted from whole blood samples taken from all patients, analyzed by flow cytometry for CD14, CD34, CD133, CD45, and vascular endothelial growth factor receptor 2 (VEGFR2), and cultured for functional analysis.
resultsCompared with patients with normal coronary endothelial function, in those with coronary endothelial dysfunction, the number of circulating CD34+/CD45(dim)/VEGFR2- cells, CD34+/CD45(dim)/CD133+/VEGFR2- cells and colony-forming units were reduced. Concentrations of CD34+/CD45-/VEGFR2+ cells did not differ between groups.
conclusionsRegulation of CD34+ cell subsets seems to differ between patients with coronary endothelial dysfunction and those with normal coronary endothelial function. Changes in specific circulating progenitor cell subsets might, therefore, be an early manifestation of atherosclerosis.
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