ArticleThe Plant cell2008
Spermidine exodus and oxidation in the apoplast induced by abiotic stress is responsible for H2O2 signatures that direct tolerance responses in tobacco.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed, 317 citations in OpenAlex.
- Exogenous Polyamines and Plant Salinity Tolerance: A Systematic Review, Evidence Map, and Family-Aware Quantitative Synthesis.Antioxidants (Basel, Switzerland) · 2026Review
- Reactive Oxygen Species in Crop Plants: Production, Detoxification, Signaling, and Molecular Cross-Talk.Plants (Basel, Switzerland) · 2026Review
- Transcriptome-level dissection provides unique insights into the salt tolerance in spelt (Triticum spelta L.).BMC plant biology · 2026Article
- Polyamine-mediated crosstalk in plant-microbe systems: implications for stress tolerance and crop protection.Frontiers in plant science · 2026Review
- PagSAMDC4a-Mediated Polyamine Synthesis Regulate Vessel Differentiation Under Drought Stress Conditions in Poplar.Plant biotechnology journal · 2025Article
- Molecular Mechanisms and Crosstalk Signaling in Soybean's Response to Water Deficit and Excess: Implications for Stress Resilience and Productivity.Plants (Basel, Switzerland) · 2025Article
- Unveiling oxidative stress: surface ozone triggers phenylpropanoid pathway shifts and metabolite rewiring in PBW-550 wheat.Plant cell reports · 2025Article
- Spermidine enhances the heat tolerance ofApplied and environmental microbiology · 2025Article
- Polyamines: pleiotropic molecules regulating plant development and enhancing crop yield and quality.Plant biotechnology journal · 2024Review
- Spermidine Improves Freezing Tolerance by Regulating HAntioxidants (Basel, Switzerland) · 2024Article
- Overexpression of OsACL5 triggers environmentally-dependent leaf rolling and reduces grain size in rice.Plant biotechnology journal · 2024Article
- Genome-wide identification of R2R3-MYB family genes and gene response to stress in ginger.The plant genome · 2024Article
- Nanobiotechnology-mediated regulation of reactive oxygen species homeostasis under heat and drought stress in plants.Frontiers in plant science · 2024Review
- L-Aminoguanidine Induces Imbalance of ROS/RNS Homeostasis and Polyamine Catabolism of Tomato Roots after Short-Term Salt Exposure.Antioxidants (Basel, Switzerland) · 2023Article
- Integrated Transcriptomic and Metabolomic Analyses Uncover the Differential Mechanism in Saline-Alkaline Tolerance betweenInternational journal of molecular sciences · 2023Article
- The chances in the redox priming of nondormant recalcitrant seeds by spermidine.Tree physiology · 2023Article
- Interactions of Polyamines and Phytohormones in Plant Response to Abiotic Stress.Plants (Basel, Switzerland) · 2023Review
- GUS Reporter-Aided Promoter Deletion Analysis ofInternational journal of molecular sciences · 2023Article
- Genetic architecture of soybean tolerance to off-target dicamba.Frontiers in plant science · 2023Article
- Polyamine Oxidase-Generated Reactive Oxygen Species in Plant Development and Adaptation: The Polyamine Oxidase-NADPH Oxidase Nexus.Antioxidants (Basel, Switzerland) · 2022Review
60 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamines (PAs) exert a protective effect against stress challenges, but their molecular role in this remains speculative. In order to detect the signaling role of apoplastic PA-derived hydrogen peroxide (H2O2) under abiotic stress, we developed a series of tobacco (Nicotiana tabacum cv Xanthi) transgenic plants overexpressing or downregulating apoplastic polyamine oxidase (PAO; S-pao and A-pao plants, respectively) or downregulating S-adenosyl-l-methionine decarboxylase (samdc plants). Upon salt stress, plants secreted spermidine (Spd) into the apoplast, where it was oxidized by the apoplastic PAO, generating H2O2. A-pao plants accumulated less H2O2 and exhibited less programmed cell death (PCD) than did wild-type plants, in contrast with S-pao and samdc downregulating plants. Induction of either stress-responsive genes or PCD was dependent on the level of Spd-derived apoplastic H2O2. Thus, in wild-type and A-pao plants, stress-responsive genes were efficiently induced, although in the latter at a lower rate, while S-pao plants, with higher H2O2 levels, failed to accumulate stress-responsive mRNAs, inducing PCD instead. Furthermore, decreasing intracellular PAs, while keeping normal apoplastic Spd oxidation, as in samdc downregulating transgenic plants, caused enhanced salinity-induced PCD. These results reveal that salinity induces the exodus of Spd into the apoplast, where it is catabolized by PAO, producing H2O2. The accumulated H2O2 results in the induction of either tolerance responses or PCD, depending also on the levels of intracellular PAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.