ArticleThe Journal of endocrinology2008
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.
Article in The Journal of endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone.Communications biology · 2022Article
- Peripheral Innervation in the Regulation of Glucose Homeostasis.Trends in neurosciences · 2021Review
- VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet-Induced Stress.Diabetes · 2020Article
- Elucidating the Relationship Between Diabetes Mellitus and Parkinson's Disease UsingFrontiers in neuroscience · 2020Review
- A role for foregut tyrosine metabolism in glucose tolerance.Molecular metabolism · 2019Article
- A novel optical tracer for VMAT2 applied to live cell measurements of vesicle maturation in cultured human β-cells.Scientific reports · 2019Article
- Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion.The Journal of biological chemistry · 2018Article
- MALDI MS Guided Liquid Microjunction Extraction for Capillary Electrophoresis-Electrospray Ionization MS Analysis of Single Pancreatic Islet Cells.Analytical chemistry · 2017Article
- Gastrointestinal dopamine as an anti-incretin and its possible role in bypass surgery as therapy for type 2 diabetes with associated obesity.Minerva endocrinologica · 2016Review
- Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.Frontiers in nutrition · 2016Article
- Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Dopamine modulates insulin release and is involved in the survival of rat pancreatic beta cells.PloS one · 2015Article
- New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2).ACS chemical biology · 2013Article
- Minireview: Dopaminergic regulation of insulin secretion from the pancreatic islet.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Localization and expression of VMAT2 aross mammalian species: a translational guide for its visualization and targeting in health and disease.Advances in pharmacology (San Diego, Calif.) · 2013Review
- Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Neurofunctional imaging of β-cell dynamics.Diabetes, obesity & metabolism · 2012Review
- The heterogeneity of focal forms of congenital hyperinsulinism.The Journal of clinical endocrinology and metabolism · 2012Article
- Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes.Molecular imaging and biology · 2011Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
Despite different embryological origins, islet beta-cells and neurons share the expression of many genes and display multiple functional similarities. One shared gene product, vesicular monoamine transporter type 2 (VMAT2, also known as SLC18A2), is highly expressed in human beta-cells relative to other cells in the endocrine and exocrine pancreas. Recent reports suggest that the monoamine dopamine is an important paracrine and/or autocrine regulator of insulin release by beta-cells. Given the important role of VMAT2 in the economy of monoamines such as dopamine, we investigated the possible role of VMAT2 in insulin secretion and glucose metabolism. Using a VMAT2-specific antagonist, tetrabenazine (TBZ), we studied glucose homeostasis, insulin secretion both in vivo and ex vivo in cultures of purified rodent islets. During intraperitoneal glucose tolerance tests, control rats showed increased serum insulin concentrations and smaller glucose excursions relative to controls after a single intravenous dose of TBZ. One hour following TBZ administration we observed a significant depletion of total pancreas dopamine. Correspondingly, exogenous L-3,4-dihydroxyphenylalanine reversed the effects of TBZ on glucose clearance in vivo. In in vitro studies of rat islets, a significantly enhanced glucose-dependent insulin secretion was observed in the presence of dihydrotetrabenazine, the active metabolite of TBZ. Together, these data suggest that VMAT2 regulates in vivo glucose homeostasis and insulin production, most likely via its role in vesicular transport and storage of monoamines in beta-cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.