ArticleBMC infectious diseases2008
Human Papillomavirus type distribution in invasive cervical cancer in Uganda.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The interplay between programmed death ligand 1 (PD-L1) expression and human papillomavirus (HPV) genotypes in cervical carcinomas: findings of a Nigerian Tertiary Hospital.The Pan African medical journal · 2024Article
- Detection of human papillomavirus infection in oral cancers reported at dental facility: assessing the utility of FFPE tissues.Medical oncology (Northwood, London, England) · 2021Article
- Cervical cancer risk perceptions, sexual risk behaviors and sexually transmitted infections among Bivalent Human Papillomavirus vaccinated and non-vaccinated young women in Uganda - 5 year follow up study.BMC women's health · 2017Article
- Acceptability of study procedures (self-collected introital swabs, blood draws and stool sample collection) by students 10-16 years for an HPV vaccine effectiveness study: a pilot study.BMC research notes · 2016Article
- Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola.The Pan African medical journal · 2016Article
- Article
- Cervical cancer screening in low-resource settings: A cost-effectiveness framework for valuing tradeoffs between test performance and program coverage.International journal of cancer · 2015Article
- Update on prevention and screening of cervical cancer.World journal of clinical oncology · 2014Review
- Article
- The burden of human papillomavirus infections and related diseases in sub-saharan Africa.Vaccine · 2013Review
- Are the currently existing anti-human papillomavirus vaccines appropriate for the developing world?Annals of medical and health sciences research · 2013Review
- Improvement of DNA extraction for human papillomavirus genotyping from formalin-fixed paraffin-embedded tissues.BioResearch open access · 2012Article
- Article
- Epidemiology of HPV genotypes in Uganda and the role of the current preventive vaccines: A systematic review.Infectious agents and cancer · 2011Article
- Comparison of human papillomavirus detection between freshly frozen tissue and paraffin embedded tissue of invasive cervical cancer.Infectious agents and cancer · 2010Article
- The usefulness of immunohistochemistry in tissue microarrays of Human Papillomavirus negative adenocarcinoma of the uterine cervix.BMC research notes · 2010Article
- Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers.BMC infectious diseases · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda.
methods191 archival cervical carcinoma samples diagnosed in the Department of Pathology, Makerere University in Kampala between 1968 and 1992 were analysed using a sensitive PCR-Reverse Hybridization Line Probe Assay.
resultsOut of the 186 cases of confirmed invasive cervical cancer in the study paraffin blocks, 114 were positive for HPV DNA. Specific HPV genotypes were identifiable in 109 cases: HPV 16, 18, 31, 35, 39, 44, 45, 51, 52 and 70. These occurred as single infections in 105 cases (96.3%) and as multiple infections in 4 cases (3.7%). HPV 16 or 18 accounted for 80% (84/105) of cases with single infection.
conclusionThe results of this study confirm the role of HPV 16 and 18 in cervical cancer pathogenesis in the Ugandan population. The results suggest that the currently available HPV vaccines against HPV 16 and 18 could possibly prevent the majority of invasive cervical cancers in Uganda.
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Registered trials
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