ArticleBMC cell biology2008
Proteomic analysis of lamellar bodies isolated from rat lungs.
Article in BMC cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 50 citations in OpenAlex.
- GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells.Cellular & molecular biology letters · 2023Article
- Article
- Review
- Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.American journal of respiratory cell and molecular biology · 2018Article
- Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity.Biophysical journal · 2015Article
- Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Apolipoprotein A-I, A-II, and H mRNA and protein accumulation sites in the developing lung in late gestation.BMC research notes · 2011Article
- Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles.PloS one · 2011Article
- Effects of perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells.Respiratory research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLamellar bodies are lysosome-related secretory granules and store lung surfactant in alveolar type II cells. To better understand the mechanisms of surfactant secretion, we carried out proteomic analyses of lamellar bodies isolated from rat lungs.
resultsWith peptide mass fingerprinting by Matrix Assisted Laser Desorption/Ionization - Time of Flight mass spectrometry, 44 proteins were identified with high confidence. These proteins fell into diverse functional categories: surfactant-related, membrane trafficking, calcium binding, signal transduction, cell structure, ion channels, protein processing and miscellaneous. Selected proteins were verified by Western blot and immunohistochemistry.
conclusionThis proteomic profiling of lamellar bodies provides a basis for further investigations of functional roles of the identified proteins in lamellar body biogenesis and surfactant secretion.
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Registered trials
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