ArticlePediatric nephrology (Berlin, Germany)2008
Vitamin D insufficiency and hyperparathyroidism in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Randomized trial of two maintenance doses of vitamin D in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Ergocalciferol decreases erythropoietin resistance in children with chronic kidney disease stage 5.Pediatric nephrology (Berlin, Germany) · 2013Trial
- Is high-dose cholecalciferol justified in children with chronic kidney disease who failed low-dose maintenance therapy?Pediatric nephrology (Berlin, Germany) · 2013Trial
- Cardiometabolic factors and vitamin D deficiency in pediatric patients with chronic kidney disease.Frontiers in nutrition · 2024Article
- Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention.Nutrients · 2023Review
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Article
- Intermittent cholecalciferol supplementation in children and teenagers followed in pediatric nephrology: data from a prospective single-center single-arm open trial.European journal of pediatrics · 2020Article
- Prevalence of Hyperparathyroidism, Mineral and Bone Disorders in Children with Advanced Chronic Kidney Disease.Indian journal of pediatrics · 2016Observational
- Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort.Pediatric nephrology (Berlin, Germany) · 2016Article
- Disordered FGF23 and mineral metabolism in children with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2014Observational
- Antibacterial responses by peritoneal macrophages are enhanced following vitamin D supplementation.PloS one · 2014Article
- A review on vitamin d deficiency treatment in pediatric patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2013Review
- Vitamin D bioavailability and catabolism in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Article
- Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bone disorders (CKD-MBD) in children.Pediatric nephrology (Berlin, Germany) · 2013Review
- Beyond mineral metabolism, is there an interplay between FGF23 and vitamin D in innate immunity?Pediatric nephrology (Berlin, Germany) · 2013Review
- Vitamin D status of children receiving chronic dialysis.Pediatric nephrology (Berlin, Germany) · 2012Article
- Vitamin D status in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2012Article
- Vitamin D in chronic kidney disease.Indian journal of pediatrics · 2012Review
- Vitamin D deficiency is common in children and adolescents with chronic kidney disease.Kidney international · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) is associated with altered calcium-phosphate homeostasis and hyperparathyroidism due to decreased activity of 1alpha-hydroxylase and impaired activation of 25-hydroxyvitamin D3 [25(OH)D3]. In some patients these problems start earlier because of vitamin D deficiency. A retrospective review of patients followed in the chronic renal insufficiency clinic at Children's Hospital of Michigan assessed the prevalence of vitamin D deficiency in CKD stages 2-4 and evaluated the effect of treatment with ergocalciferol on serum parathormone (PTH). Blood levels of 1,25 dihydroxyvitamin D3, 25(OH)D3, and parathormone (PTH) were examined in 57 children (40 boys; mean age 10.6 years). Of 57 subjects, 44 (77.2%) had 25(OH)D3 levels < or =30 ng/ml, with overall mean of 26.4 +/- 14.3 ng/ml. PTH for patients with 25(OH)D3 levels >30 ng/ml was 67.84 +/- 29.09 ng/ml and in the remaining patients was elevated, at 120.36 +/- 86.42 ng/ml (p = 0.05). Following ergocalciferol treatment (22), PTH decreased from 122.13 +/- 82.94 ng/ml to 80.14 +/- 59.24 ng/ml (p < 0.001) over a period of 3 months. We conclude that vitamin D deficiency is common in children with CKD stages 2-4 and is associated with hyperparathyroidism in the presence of normal 1,25 dihydroxyvitamin D3. Its occurrence before significant renal impairment is noteworthy. Early diagnosis and appropriate treatment is emphasized.
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