ReviewCell and tissue research2008
Regenerating cochlear hair cells: quo vadis stem cell.
Review in Cell and tissue research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Inner Ear Organoid as a Preclinical Model of Hearing Regeneration: Progress and Applications.Stem cell reviews and reports · 2025Review
- Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells.Experimental and therapeutic medicine · 2022Article
- Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.Development (Cambridge, England) · 2019Review
- New molecular therapies for the treatment of hearing loss.Pharmacology & therapeutics · 2019Review
- Hearing regeneration and regenerative medicine: present and future approaches.Archives of medical science : AMS · 2019Article
- ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA.Cell death & disease · 2018Article
- MicroRNAs: effective elements in ear-related diseases and hearing loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Review
- Comparing the cultivated cochlear cells derived from neonatal and adult mouse.Journal of translational medicine · 2014Article
- The convergence of cochlear implantation with induced pluripotent stem cell therapy.Stem cell reviews and reports · 2012Review
- Concise review: Inner ear stem cells--an oxymoron, but why?Stem cells (Dayton, Ohio) · 2012Review
- Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration.Journal of speech, language, and hearing research : JSLHR · 2011Review
- A review of gene delivery and stem cell based therapies for regenerating inner ear hair cells.Journal of functional biomaterials · 2011Article
- Regeneration of Hair Cells: Making Sense of All the Noise.Pharmaceuticals (Basel, Switzerland) · 2011Article
- Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Growth hormone promotes hair cell regeneration in the zebrafish (Danio rerio) inner ear following acoustic trauma.PloS one · 2011Article
- Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea.PloS one · 2010Article
- Article
- The challenge of hair cell regeneration.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Feathers and fins: non-mammalian models for hair cell regeneration.Brain research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.