Trial reportPsychopharmacology2008
Dissociable effects of acute antidepressant drug administration on subjective and emotional processing measures in healthy volunteers.
Trial report in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- A systematic review of the pharmacological modulation of autobiographical memory specificity.Frontiers in psychology · 2022Pooled it
- Pharmacological manipulations of judgement bias: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2020Pooled it
- The effect of ketamine on affective modulation of the startle reflex and its resting-state brain correlates.Scientific reports · 2023Trial
- The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial.Psychological medicine · 2022Trial
- Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.Psychopharmacology · 2016Trial
- Early effects of duloxetine on emotion recognition in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2015Trial
- Study protocol for the randomised controlled trial: antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study).BMC psychiatry · 2013Trial
- Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Effects of amphetamine on reactivity to emotional stimuli.Psychopharmacology · 2012Trial
- Short-term duloxetine administration affects neural correlates of mood-congruent memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- A single dose of mirtazapine modulates neural responses to emotional faces in healthy people.Psychopharmacology · 2010Trial
- Acute administration of the cannabinoid CB1 antagonist rimonabant impairs positive affective memory in healthy volunteers.Psychopharmacology · 2009Trial
- Early effects of mirtazapine on emotional processing.Psychopharmacology · 2009Trial
- Negative bias in encoding and recall memory in depressed patients with inadequate response to antidepressant medication.Psychopharmacology · 2026Article
- Probiotics reduce negative mood over time: the value of daily self-reports in detecting effects.Npj mental health research · 2025Article
- Difficult lives explain depression better than broken brains.Molecular psychiatry · 2024Article
- Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.Psychopharmacology · 2021Review
- Interferon-α induces negative biases in emotional processing in patients with hepatitis C virus infection: a preliminary study.Psychological medicine · 2018Article
- Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults.Cannabis and cannabinoid research · 2017Article
- Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications.International journal of bipolar disorders · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe have previously shown that single doses of serotonin-selective and noradrenaline-selective antidepressant agents produce positive biases in measures of emotional processing in healthy volunteers. The aim of the present study was to confirm and extend this finding by studying the effects of a single dose of the selective serotonin and noradrenaline re-uptake inhibitor, duloxetine. MATERIALS AND
methodsHealthy volunteers were randomly allocated to double-blind administration of either duloxetine 60 mg orally or placebo. Participants then completed a battery of emotional-processing tasks measuring facial expression recognition, emotional memory and emotion-potentiated startle. Subjective state was measured using visual analogue scales throughout the test period.
resultsDuloxetine enhanced the recognition of both disgusted and happy facial expressions and increased memory intrusions for positive personality characteristics in the free recall test. There were no significant effects on startle responses. However, duloxetine was not well tolerated and was associated with a high level of negative subjective effects.
conclusionsDespite the induction of negative subjective effects after duloxetine administration, some positive effects on emotional processing were seen in line with acute administration of serotonin-selective and noradrenaline-selective antidepressant agents. These results confirm the induction of fast changes in emotional processing in healthy volunteer groups and suggest a mechanism by which antidepressants may act in depression. Further studies are required to assess whether positive effects on emotional processing are more selective at a lower dose of duloxetine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.