SynthesisIntensive care medicine2008
The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis.
Synthesis in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study.BMC medical research methodology · 2021Pooled it
- Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.German medical science : GMS e-journal · 2015Guideline
- Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis.Intensive care medicine · 2010Pooled it
- The Addition of Dexmedetomidine to Analgesia for Patients After Abdominal Operations: A Prospective Randomized Clinical Trial.World journal of surgery · 2017Trial
- Impact of sedation with propofol and/or sufentanil on short-term outcomes in patients admitted to the intensive care unit: A retrospective study.The Journal of international medical research · 2026Article
- Study protocol for the use of propofol in adult intensive care unit patients: a secondary analysis of an extensive international database.Critical care science · 2026Article
- Determination of the Long-Term Stability of Propofol in Human Plasma Frozen for Eight Years and Quantified by UHPLC-MS/MS.International journal of analytical chemistry · 2025Article
- Effects of coenzyme Q10 in a propofol infusion syndrome model of rabbits.Asian biomedicine : research, reviews and news · 2023Article
- Assessment and Management of Delirium in the Pediatric Intensive Care Unit: A Review.Journal of pediatric intensive care · 2023Review
- Seeking the Light in Intensive Care Unit Sedation: The Optimal Sedation Strategy for Critically Ill Patients.Frontiers in medicine · 2022Review
- Influence of Sevoflurane Inhalation Anesthesia on Clinical Outcomes of Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours.Journal of Korean medical science · 2021Article
- Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study.BMJ open · 2021Article
- Evidence-Based Guideline for Adult Sedation, Pain Assessment, and Analgesia in a Low Resource Setting Intensive Care Unit: Review Article.International journal of general medicine · 2020Review
- Propofol infusion syndrome: a structured literature review and analysis of published case reports.British journal of anaesthesia · 2019Review
- Propofol Infusion Syndrome in the Postoperative Period of a Kidney Transplant.Case reports in nephrology · 2019Article
- Experienced Use of Dexmedetomidine in the Intensive Care Unit: A Report of a Structured Consensus.Turkish journal of anaesthesiology and reanimation · 2018Article
- Delirium in the Cardiac Intensive Care Unit.Journal of the American Heart Association · 2018Review
- Analgesia, sedation and arousal status in burn patients: the gap between recommendations and current practices.Annals of burns and fire disasters · 2017Article
- Propofol or benzodiazepines for short- and long-term sedation in intensive care units? An economic evaluation based on meta-analytic results.ClinicoEconomics and outcomes research : CEOR · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of using propofol for medium and long-term sedation on mortality and length of intensive care unit (ICU) stay of critically ill adult patients.
designRandomised controlled studies comparing propofol with an alternative sedative agent in critically ill adult patients were included without language restriction from the Cochrane Controlled Trial Register (2007 issue 3), EMBASE, and MEDLINE databases (1966 to 1 December 2007). Two reviewers reviewed the quality of the studies and performed data extraction independently. MEASUREMENTS AND
resultsSixteen randomised controlled studies with a total of 1,386 critically ill adult patients were considered. Nine of the pooled studies (56%) limited the doses of propofol infusion to <6 mg/kg h(-1). Mortality was not significantly different between patients sedated with propofol, or an alternative sedative agent (odds ratio [OR] 1.05, 95% confidence interval [CI] 0.80-1.38, P = 0.74; I(2) = 0%). Using propofol for medium and long-term sedation was associated with a significant reduction in length of ICU stay (overall weighted-mean-difference [WMD] in days -0.99, 95%CI -1.51 to -0.47, P = 0.0002; I(2) = 82.26%) when compared to an alternative sedative agent; however, this benefit became insignificant (overall WMD in days -0.98, 95%CI -2.86 to 0.89, P = 0.30; I(2) = 78.8%) when the comparison was limited to between propofol and midazolam.
conclusionsUsing propofol for prolonged sedation in critically ill patients appears to be safe and may reduce duration of mechanical ventilation. It reduces the length of ICU stay when compared to long acting benzodiazepines, but not when compared to midazolam.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.