ArticlePloS one2008
Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Concurrent Brain Subregion Microgliosis in an HLA-II Mouse Model of Group A Streptococcal Skin Infection.Microorganisms · 2023Article
- Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment.Oncoimmunology · 2021Review
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- Multifunctional Nanotherapeutics for the Treatment of neuroAIDS in Drug Abusers.Scientific reports · 2018Article
- Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy.AIDS (London, England) · 2018Article
- Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study.Journal of neurovirology · 2018Article
- Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.Oncotarget · 2016Article
- ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.Nature communications · 2016Article
- HIV-infected microglia mediate cathepsin B-induced neurotoxicity.Journal of neurovirology · 2015Article
- Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus.Brain, behavior, and immunity · 2014Article
- Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Review
- Proteomics analysis of the DF-1 chicken fibroblasts infected with avian reovirus strain S1133.PloS one · 2014Article
- Modulation of neuronal proteome profile in response to Japanese encephalitis virus infection.PloS one · 2014Article
- Astrocyte Dysfunctions and HIV-1 Neurotoxicity.Journal of AIDS & clinical research · 2013Article
- Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.Nucleic acids research · 2013Article
- HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis.PloS one · 2013Article
- Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy.PloS one · 2013Article
- HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder.Neurochemistry international · 2012Article
- Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundHIV-1-infected and immune competent brain mononuclear phagocytes (MP; macrophages and microglia) secrete cellular and viral toxins that affect neuronal damage during advanced disease. In contrast, astrocytes can affect disease by modulating the nervous system's microenvironment. Interestingly, little is known how astrocytes communicate with MP to influence disease. METHODS AND
findingsMP-astrocyte crosstalk was investigated by a proteomic platform analysis using vesicular stomatitis virus pseudotyped HIV infected murine microglia. The microglial-astrocyte dialogue was significant and affected microglial cytoskeleton by modulation of cell death and migratory pathways. These were mediated, in part, through F-actin polymerization and filament formation. Astrocyte secretions attenuated HIV-1 infected microglia neurotoxicity and viral growth linked to the regulation of reactive oxygen species.
conclusionsThese observations provide unique insights into glial crosstalk during disease by supporting astrocyte-mediated regulation of microglial function and its influence on the onset and progression of neuroAIDS. The results open new insights into previously undisclosed pathogenic mechanisms and open the potential for biomarker discovery and therapeutics that may influence the course of HIV-1-mediated neurodegeneration.
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