ArticleMicrocirculation (New York, N.Y. : 1994)2008
Inhibition of angiogenesis by high salt diet is associated with impaired muscle performance following chronic muscle stimulation.
Article in Microcirculation (New York, N.Y. : 1994), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Endurance exercise protects agingBiology open · 2020Article
- NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Biocompatibility of Four Common Orthopedic Biomaterials Following a High-Salt Diet: An In Vivo Study.International journal of molecular sciences · 2017Article
- Titanium Implant Impairment and Surrounding Muscle Cell Death Following High-Salt Diet: An In Vivo Study.PloS one · 2016Article
- Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin II levels.Applied & translational genomics · 2015Article
- Bone marrow mononuclear cell angiogenic competency is suppressed by a high-salt diet.American journal of physiology. Cell physiology · 2014Article
- Possible Involvement of CSPG4 in Promoting Endothelial Cell Migration and Contributing to Angiogenesis during Skeletal Muscle Regeneration and Development in the Rat.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveHigh dietary salt has been demonstrated to inhibit angiogenesis in skeletal muscle. The purpose of this study was to determine whether high salt impairs steady state muscle performance following a chronic stimulation protocol.
methodsSprague-Dawley rats were placed on a control diet (CD, 0.4% NaCl) or high salt diet (HSD, 4.0% NaCl) prior to implantation of an electrical muscle stimulator. In chronically stimulated animals, hind limb muscles were stimulated to contract eight hours daily for seven days. Sham animals received a stimulator that was never activated.
resultsFollowing chronic stimulation, tibialis anterior (TA) muscles of animals on CD demonstrated an 84.6% increase in force of contraction at the end of an acute stimulation bout relative to sham animals fed CD. Decreased muscle fatigue was associated with an increase in capillaries per TA fiber (C:F). Chronic stimulation in HSD rats induced a smaller improvement (52.2%) in final force compared to HSD sham rats. This impairment of muscle performance in high salt-fed rats correlated with inhibited angiogenesis. Infusion of angiotensin II in HSD animals restored angiogenesis and muscle fatigue to CD levels.
conclusionsThis study suggests that angiogenic inhibition by high salt is associated with impaired skeletal muscle performance following chronic stimulation.
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