Evidence map›Paper›PMID 18574614›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2008

Age-specific familial risks of anxiety. A nation-wide epidemiological study from Sweden.

Xinjun Li, Jan Sundquist, Kristina Sundquist

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Assessment and Treatment of Anxiety Among Children and Adolescents.Focus (American Psychiatric Publishing) · 2017
    Review
  4. Article
  5. Cross-generational influences on childhood anxiety disorders: pathways and mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2016
    Review
  6. Parental involvement: contribution to childhood anxiety and its treatment.Clinical child and family psychology review · 2014
    Review
  7. Family factors in the development and management of anxiety disorders.Clinical child and family psychology review · 2012
    Review
  8. Childhood adversity and chronicity of mood disorders.European archives of psychiatry and clinical neuroscience · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xinjun LiCenter for Family and Community Medicine, Karolinska Institute, Alfred Nobels allé 12, 141 83 Huddinge, Sweden. xinjun.li@ki.se
Jan Sundquist
Kristina Sundquist
Karolinska Institutet · SE

Funding

Mothers, Places, and Preterm BirthR01HD052848 · NICHD · LUNDS UNIVERSITET · PI SUNDQUIST, JAN O · 2007 to 2010
$1.8M
NICHD NIH HHS R01 HD052848-01 A1
6 · The paper itself

Abstract

objectiveFamilial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.

methodsThe Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases of men and women with mothers and/or fathers affected by anxiety, compared with men and women whose mothers and/or fathers were not affected by anxiety.

resultsA total of 55,642 and 57,196 cases of anxiety were recorded in offspring and parents, respectively. The overall significant SIRs among men and women with a mother, father or both parents hospitalized for anxiety varied between 1.90 and 5.10. Maternal transmission of anxiety was slightly higher than paternal and the highest SIRs were found in the youngest age groups and among those with both parents affected by anxiety. The degree of parental transmission of anxiety was similar for both men and women.

conclusionsThis study has provided the first data on age-specific familial clustering of anxiety, based on medically confirmed records. The risks were so high that hereditary factors were considered to be likely to contribute, possibly modified by environmental factors. Age-specific risks tables would be helpful for clinical counseling.

Indexed as

Family HealthAdolescentAdultAgedAged, 80 and overAge FactorsAge of OnsetAnxietyChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMale

Identifiers

PMID18574614
OpenAlexW1573409978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.