Trial reportEuropean archives of psychiatry and clinical neuroscience2008
Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment.
Trial report in European archives of psychiatry and clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06577727 (A Study to Collect Data to Build Artificial Intelligence Derived Algorithms for Estimating Iron Status of Children), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Collect Data to Build Artificial Intelligence Derived Algorithms for Estimating Iron Status of Children (FERROUS 2)
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Pooled it
- Systematic review of neuroimaging findings in children and young adults with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Blood lead concentrations in children with iron deficiency anemia: a systematic review and meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Interventions for Addressing Anemia Among Children and Adolescents: An Overview of Systematic Reviews.Frontiers in pediatrics · 2020Pooled it
- Impact of Beef and Beef Product Intake on Cognition in Children and Young Adults: A Systematic Review.Nutrients · 2019Pooled it
- Genetic factors associated with iron storage in Australian blood donors.Blood transfusion = Trasfusione del sangue · 2018Trial
- Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.The Journal of nutrition · 2017Trial
- Trial
- Improvements in iron status and cognitive function in young women consuming beef or non-beef lunches.Nutrients · 2013Trial
- Perspective: use of beef in a dietary intervention as an effective strategy for improving cognition in young adult females.Frontiers in nutrition · 2026Article
- A Noninvasive Approach to Assess the Prevalence of and Factors Associated With Anemia Risk in Malaysian Children Under Three Years of Age: Cross-Sectional Study.JMIR pediatrics and parenting · 2025Article
- Persistent impact of antenatal maternal anaemia on child brain structure at 6-7 years of age: a South African child health study.BMC medicine · 2025Article
- Associations Between Lifetime Histories of Iron Deficiency, Anxiety, Depression and Multiple Pain Conditions: An Observational Study Using a Large-Scale National Database.Journal of pain research · 2025Article
- Impact of Iron Intake and Reserves on Cognitive Function in Young University Students.Nutrients · 2024Article
- Associations of iron deficiency and depressive symptoms among young adult males and Females: NHANES 2017 to 2020.Preventive medicine reports · 2024Article
- Next generation sequencing to identify iron status and individualise blood donors' experience.Blood transfusion = Trasfusione del sangue · 2023Article
- Article
- Association of Maternal and Child Anemia With Brain Structure in Early Life in South Africa.JAMA network open · 2022Article
- Associations between red blood cell indices and iron status and neurocognitive function in young adults: Evidence from memory and executive function tests and event-related potentials.Annals of the New York Academy of Sciences · 2022Article
- P300, a tool for cognitive assessment in women with iron deficiency anemia: A systematic review.Journal of family medicine and primary care · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many investigators found that iron deficiency anemia (IDA) had a great influence on cognitive functions in infants and children. However, studies of such topic in adults are few and controversial. We prospectively assessed the possible influence of IDA and iron supplementation (for 3 months) on cognitive function and intelligence of 28 young adults with IDA. We used group of hematological, cognitive, neurophysiological tests for assessment including: mini-mental state examination (MMSE), Wechsler memory scale-revised (WMS-R), Wechsler adult intelligence scale-revised (WAIS-R), event-related potentials (ERPs), and electroencephalography (EEG). Compared to controls, patients demonstrated lower scores of different cognitive tests (MMSE, WMS-R, and WAIS-R), which showed significant improvement after treatment. Prolongation of ERPs latencies (N200 and P300) and reduction in their amplitudes (P200 and P300) were identified with significant increase in amplitude occurred after treatment. EEG abnormalities were observed in 55% of patients which showed improvement in 35% after treatment. Positive correlation was identified before and after treatment between hemoglobin levels and MMSE (P=0.01, 0.05), total verbal (P=0.04) and performance (P=0.05, 0.04) IQ scores. Negative correlation was identified between before and after treatment between P300 latency and total IQ of WAIS-R (P=0.03, 0.008) and hemoglobin level (P=0.4, 0.01). Positive correlation was found before and after treatment between P300 amplitude and total IQ (P=0.028, 0.01) and serum iron (P=0.01, 0.001). In conclusion, IDA is a significant factor in cognitive performance in adult population, which can be partially reversed by treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.