ArticleMolecular genetics and genomics : MGG2008
Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana.
Article in Molecular genetics and genomics : MGG, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed, 140 citations in OpenAlex.
- Structural characterization of OsPDIL2-3, a rice protein disulfide isomerase involved in prolamin accumulation.The Biochemical journal · 2026Article
- Genome wide characterization and expression profiling of protein disulfide isomerase (PDI) gene family members in watermelon under cold stress.Genes & genomics · 2026Article
- Domestication history and genetic changes for the newly evolved flower color in the ornamental plantHorticulture research · 2025Article
- The TRAPPC8/TRS85 subunit of the Arabidopsis TRAPPIII tethering complex regulates endoplasmic reticulum function and autophagy.Plant physiology · 2025Article
- Relationship between Protein, MicroRNA Expression in Extracellular Vesicles and Rice Seed Vigor.International journal of molecular sciences · 2024Article
- The root-knot nematode effector MiEFF12 targets the host ER quality control system to suppress immune responses and allow parasitism.Molecular plant pathology · 2024Article
- Heterologous expression of influenza haemagglutinin leads to early and transient activation of the unfolded protein response in Nicotiana benthamiana.Plant biotechnology journal · 2024Article
- Protein disulfide isomerase-9 interacts with the lumenal region of the transmembrane endoplasmic reticulum stress sensor kinase, IRE1, to modulate the unfolded protein response inFrontiers in plant science · 2024Article
- Endoplasmic reticulum calnexins participate in the primary root growth response to phosphate deficiency.Plant physiology · 2023Article
- A Proteomic Analysis for the Red SeaweedBiology · 2023Article
- Subcellular positioning during cell division and cell plate formation in maize.Frontiers in plant science · 2023Article
- The sieve-element endoplasmic reticulum: A focal point of phytoplasma-host plant interaction?Frontiers in microbiology · 2023Article
- Development of a GFP biosensor reporter for the unfolded protein response-signaling pathway in plants: incorporation of the bZIP60 intron into the GFP gene.Plant signaling & behavior · 2022Article
- ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth.Plants (Basel, Switzerland) · 2022Review
- Environmental Signals Act as a Driving Force for Metabolic and Defense Responses in the Antarctic PlantPlants (Basel, Switzerland) · 2022Article
- Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants.Antioxidants (Basel, Switzerland) · 2022Review
- Expression Characterization ofInternational journal of molecular sciences · 2022Article
- Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding.Plant physiology · 2022Article
- Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination.Molecular plant · 2021Article
- The thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses.BMC plant biology · 2021Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins entering the secretory pathway of eukaryotic cells are folded into their native structures in the endoplasmic reticulum (ER). Disruption of protein folding causes ER stress and activates signaling cascades, designated the unfolded protein response (UPR), that restore folding capacity. In mammals and yeast, the protein disulfide isomerases (PDIs) are key protein folding catalysts activated during UPR. However, little is known about the response of PDI genes to UPR in plants. In Arabidopsis thaliana, we identified 12 PDI genes that differed in polypeptide length, presence of signal peptide and ER retention signal, and the number and positions of thioredoxin and transmembrane domains. AtPDI gene expression was investigated in different tissues, in response to chemically induced UPR, and in null mutants of UPR signaling mediators (AtIRE1-2 and AtbZIP60). The expression of six AtPDI genes was significantly up-regulated by UPR and sharply attenuated by the transcription inhibitor, actinomycin D, indicating UPR induced AtPDI gene transcription. AtPDI and BIP2 (Binding protein) gene expression was not affected in the Atire1-2 mutant exposed to UPR, however, the expression of four AtPDI genes was decreased in the Atbzip60 mutant. We proposed that additional UPR signaling factors complement AtbZIP60 in the activation of AtPDI gene expression during ER stress in plants.
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