ArticleMolecular psychiatry2010
The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
Article in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.Molecular genetics & genomic medicine · 2018Pooled it
- The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Trial
- Interaction between vitamin E intake and a COMT gene variant on colorectal cancer risk among Korean adults: a case-control study.Epidemiology and health · 2023Article
- Polymorphisms inGenes · 2022Article
- Article
- Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits.The pharmacogenomics journal · 2019Article
- Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults.Brain structure & function · 2016Article
- The catechol-o-methyltransferase Val¹⁵⁸Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.Scientific reports · 2015Article
- Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children.Journal of toxicology and environmental health. Part A · 2014Article
- Schooling and variation in the COMT gene: the devil is in the details.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Genes and epigenetic processes as prospective pain targets.Genome medicine · 2013Review
- Review
- COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits.Genes, brain, and behavior · 2010Article
- Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.Annals of the New York Academy of Sciences · 2010Review
- Prefrontal-related functional connectivities within the default network are modulated by COMT val158met in healthy young adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Genes, cognition and brain through a COMT lens.Neuroscience · 2009Review
- Global variation in CYP2C8-CYP2C9 functional haplotypes.The pharmacogenomics journal · 2009Article
- [Correlations between risk gene variants for schizophrenia and brain structure anomalies].Der Nervenarzt · 2009Review
- Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene.The pharmacogenomics journal · 2008Article
- Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Genetic variation at the catechol-O-methyltransferase (COMT) gene has been significantly associated with risk for various neuropsychiatric conditions such as schizophrenia, panic disorder, bipolar disorders, anorexia nervosa and others. It has also been associated with nicotine dependence, sensitivity to pain and cognitive dysfunctions especially in schizophrenia. The non-synonymous single nucleotide polymorphism (SNP) in exon 4--Val108/158Met--is the most studied SNP at COMT and is the basis for most associations. It is not, however, the only variation in the gene; several haplotypes exist across the gene. Some studies indicate that the haplotypic combinations of alleles at the Val108/158Met SNP with those in the promoter region and in the 3'-untranslated region are responsible for the associations with disorders and not the non-synonymous SNP by itself. We have now studied DNA samples from 45 populations for 63 SNPs in a region of 172 kb across the region of 22q11.2 encompassing the COMT gene. We focused on 28 SNPs spanning the COMT-coding region and immediately flanking DNA, and found that the haplotypes are from diverse evolutionary lineages that could harbor as yet undetected variants with functional consequences. Future association studies should be based on SNPs that define the common haplotypes in the population(s) being studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.