ArticleBritish journal of pharmacology2008
Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat.
Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies.Frontiers in pharmacology · 2020Review
- Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights.British journal of pharmacology · 2020Article
- Interactions between renal vascular resistance and endothelium-derived hyperpolarization in hypertensive rats in vivo.Physiological reports · 2019Article
- Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling.Frontiers in physiology · 2018Article
- Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women.American journal of hypertension · 2017Article
- 11,12-Epoxyeicosatrienoic acid induces vasodilator response in the rat perfused mesenteric vasculature.Autonomic & autacoid pharmacology · 2017Article
- Endothelial Function in Hypertension: Victim or Culprit?Journal of clinical hypertension (Greenwich, Conn.) · 2015Review
- Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.British journal of pharmacology · 2015Review
- Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.Pflugers Archiv : European journal of physiology · 2015Article
- Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto-Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis.Pflugers Archiv : European journal of physiology · 2014Article
- No independent, but an interactive, role of calcium-activated potassium channels in human cutaneous active vasodilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Inducible endothelium-derived hyperpolarizing factor: role of the 15-lipoxygenase-EDHF pathway.Journal of cardiovascular pharmacology · 2013Review
- Effect of SWL on renal hemodynamics: could a change in renal artery contraction-relaxation responses be the cause?Urological research · 2012Article
- KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.British journal of pharmacology · 2012Article
- Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.The Journal of biological chemistry · 2012Article
- Endothelium-mediated control of vascular tone: COX-1 and COX-2 products.British journal of pharmacology · 2011Review
- COX-mediated endothelium-dependent contractions: from the past to recent discoveries.Acta pharmacologica Sinica · 2010Review
- Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets.Current hypertension reports · 2010Review
- Endothelial dysfunction: a strategic target in the treatment of hypertension?Pflugers Archiv : European journal of physiology · 2010Review
- Robert F. Furchgott, Nobel laureate (1916-2009)--a personal reflection.British journal of pharmacology · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
background and purposeExperiments were designed to determine the modulation by nitric oxide (NO) and endothelium-dependent hyperpolarizations (EDHF-mediated responses) of endothelium-dependent contractions in renal arteries of normotensive and hypertensive rats. EXPERIMENTAL APPROACH: Rings, with or without endothelium, of renal arteries of 8-month-old Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were suspended in myographs for isometric force recording. KEY
resultsACh evoked relaxations in preparations contracted with phenylephrine. L-NAME (inhibitor of NOS) attenuated (WKY) or abolished (SHR) these relaxations. TRAM-34 plus UCL 1684 (inhibitors of EDHF-mediated responses) did not decrease the relaxation, except in rings of WKY when L-NAME was also present. High concentrations of ACh caused a secondary increase in tension, augmented in rings of WKY by L-NAME or TRAM-34 plus UCL 1684. The increase in tension was prevented by indomethacin. Under baseline tension, ACh induced endothelium-dependent contractions, prevented by indomethacin (COX inhibitor) or terutroban (TP receptor antagonist). The calculated endothelium-dependent contractions were larger in rings of SHR compared with those of WKY. In preparations of SHR, the contractions were augmented by L-NAME in the presence of SC19220 (EP-1 receptor antagonist). In arteries of WKY, the endothelium-dependent contractions were augmented by TRAM-34 plus UCL 1684. The responses were reduced by SC19220. CONCLUSIONS AND IMPLICATIONS: In the renal artery of the rat, EDCF-mediated contractions are augmented by hypertension. The endothelium-dependent contractions are facilitated by NOS inhibition (in the presence of an EP-1 receptor antagonist) and by the withdrawal of EDHF-mediated responses.
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