ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2008
Neuroglobin and cytoglobin distribution in the anterior eye segment: a comparative immunohistochemical study.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment.bioRxiv : the preprint server for biology · 2025Article
- Energy Shortage in Human and Mouse Models of SLC4A11-Associated Corneal Endothelial Dystrophies.Investigative ophthalmology & visual science · 2020Article
- Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.Biological research · 2019Article
- Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Characterizing the normal proteome of human ciliary body.Clinical proteomics · 2013Article
- The anti-apoptotic role of neuroglobin.Cells · 2012Article
- Article
- Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage.The American journal of pathology · 2011Article
- Age-related gene response of human corneal endothelium to oxidative stress and DNA damage.Investigative ophthalmology & visual science · 2011Article
- Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues.Cancer cell international · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
This study provides a detailed description of immunolocalization of two oxygen-binding proteins, neuroglobin (Ngb) and cytoglobin (Cygb), in the anterior segment of healthy human and canine eyes. Specific antibodies against Ngb and Cygb were used to examine their distribution patterns in anterior segment structures including the cornea, iris, trabecular meshwork, canal of Schlemm, ciliary body, and lens. Patterns of immunoreactivity (IR) were imaged with confocal scanning laser and conventional microscopy. Analysis of sectioned human and canine eyes showed Ngb and Cygb IR in the corneal epithelium and endothelium. In the iris, Ngb and Cygb IR was localized to the anterior border and the stroma, iridal sphincter, and dilator muscle. In the iridocorneal angle, Ngb and Cygb were detected in endothelial cells of the trabecular meshwork and canal of Schlemm in human. In the ciliary body, Ngb and Cygb IR was localized to the non-pigmented ciliary epithelium of the pars plana and pars plicata and in ciliary body musculature. Ngb and Cygb distribution was similar and colocalized within the same structures of healthy human and canine anterior eye segments. Based on their immunolocalization and previously reported biochemical features, we hypothesize that Ngb and Cygb may function as scavengers of reactive oxygen species. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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