ArticleProceedings of the National Academy of Sciences of the United States of America2008
Remodeling the exocrine pancreas at metamorphosis in Xenopus laevis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Development and metamorphosis in frogs deficient in the thyroid hormone transporter MCT8.General and comparative endocrinology · 2023Article
- Insufficiency of Thyroid Hormone in Frog Metamorphosis and the Role of Glucocorticoids.Frontiers in endocrinology · 2019Review
- Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.Journal of endocrinology, diabetes & obesity · 2014Article
- Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells.The Journal of biological chemistry · 2013Article
- Developmental origins of a novel gut morphology in frogs.Evolution & development · 2013Article
- Cartilage on the move: cartilage lineage tracing during tadpole metamorphosis.Development, growth & differentiation · 2012Article
- Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis.Development genes and evolution · 2011Article
- Transdifferentiation of tadpole pancreatic acinar cells to duct cells mediated by Notch and stromelysin-3.Developmental biology · 2011Article
- Apoptosis in amphibian organs during metamorphosis.Apoptosis : an international journal on programmed cell death · 2010Review
- Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Cell-cell interactions during remodeling of the intestine at metamorphosis in Xenopus laevis.Developmental biology · 2009Article
- Xenopus pancreas development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Review
- Remodeling of insulin producing beta-cells during Xenopus laevis metamorphosis.Developmental biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At metamorphosis the Xenopus laevis tadpole exocrine pancreas remodels in two stages. At the climax of metamorphosis thyroid hormone (TH) induces dedifferentiation of the entire exocrine pancreas to a progenitor state. The organ shrinks to 20% of its size, and approximately 40% of its cells die. The acinar cells lose their zymogen granules and approximately 75% of their RNA. The mRNAs that encode exocrine-specific proteins (including the transcription factor Ptf1a) undergo almost complete extinction at climax, whereas PDX-1, Notch-1, and Hes-1, genes implicated in differentiation of the progenitor cells, are activated. At the end of spontaneous metamorphosis when the endogenous TH has reached a low level, the pancreas begins to redifferentiate. Exogenous TH induces the dedifferentiation phase but not the redifferentation phase. The tadpole pancreas lacks the mature ductal system that is found in adult vertebrate pancreases, including the frog. Exocrine pancreases of transgenic tadpoles expressing a dominant negative form of the TH receptor controlled by the elastase promoter are resistant to TH. They do not shrink when subjected to TH. Their acinar cells do not dedifferentiate at climax, nor do they down-regulate exocrine-specific genes or activate Notch-1 and Hes-1. Even 2 months after metamorphosis these frogs have not developed a mature ductal system and the acinar cells are abnormally arranged. The TH-dependent dedifferentiation of the tadpole acinar cells at climax is a necessary step in the formation of a mature frog pancreas.
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