Evidence map›Paper›PMID 18574103›Full record

ArticleThe Biological bulletin2008

The sea urchin genome as a window on function.

Stefan C Materna, R Andrew Cameron

Abstract read
In one paragraph

Article in The Biological bulletin, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stefan C MaternaDivision of Biology 156-29, California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, USA.
R Andrew Cameron

Funding

Transcriptional Casualty in Embryonic Morphogenesis: from the Specifications GRNP01HD037105 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI DAVIDSON, ERIC H · 1999 to 2018
$27.1M
Gene Library Resource for the Sea Urchin S. purpuratusP40OD010959 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAMERON, ROBERT ANDREW · 2012 to 2016
$2.5M
NICHD NIH HHS P01 HD037105NIH HHS P40 OD010959
6 · The paper itself

Abstract

The emphasis on the sequencing of genomes seems to make this task an end in itself. However, genome sequences and the genes that are predicted from them are really an opportunity to examine the biological function of the organism constructed by that genome. This point is illustrated here by examples in which the newly annotated gene complement reveals surprises about the way Strongylocentrotus purpuratus, the purple sea urchin, goes about its business. The three topics considered here are the nature of the innate immune system; the unexpected complexity of sensory function implied by genes encoding sensory proteins; and the remarkable intricacy of the regulatory gene complement in embryogenesis.

Indexed as

GenomeAnimalsGene Expression Regulation, DevelopmentalImmune SystemSensory Receptor CellsStrongylocentrotus purpuratus

Identifiers

PMID18574103
PMCPMC3981829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.