ArticleThe Journal of cell biology2008
ERK5 promotes Src-induced podosome formation by limiting Rho activation.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Article
- Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.Biomolecules · 2021Review
- Differential role for PAK1 and PAK4 during the invadopodia lifecycle.Small GTPases · 2019Article
- Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2019Article
- Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.Acta biomaterialia · 2018Article
- PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.Oncotarget · 2016Article
- Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.Cell cycle (Georgetown, Tex.) · 2016Article
- Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling.Oncotarget · 2015Article
- Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells.The Prostate · 2014Article
- p53 in cell invasion, podosomes, and invadopodia.Cell adhesion & migration · 2014Review
- Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces.Cell reports · 2013Article
- Overexpression of MEKK2 is associated with colorectal carcinogenesis.Oncology letters · 2013Article
- A novel high throughput invasion screen identifies host actin regulators required for efficient cell entry by Toxoplasma gondii.PloS one · 2013Article
- MEK5/ERK5 pathway: the first fifteen years.Biochimica et biophysica acta · 2012Review
- Targeting the BMK1 MAP kinase pathway in cancer therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Bone metastasis in prostate cancer: emerging therapeutic strategies.Nature reviews. Clinical oncology · 2011Review
- The regulation of osteoclast function and bone resorption by small GTPases.Small GTPases · 2011Article
- Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Increased Src activity, often associated with tumorigenesis, leads to the formation of invasive adhesions termed podosomes. Podosome formation requires the function of Rho family guanosine triphosphatases and reorganization of the actin cytoskeleton. In addition, Src induces changes in gene expression required for transformation, in part by activating mitogen-activated protein kinase (MAPK) signaling pathways. We sought to determine whether MAPK signaling regulates podosome formation. Unlike extracellular signal-regulated kinase 1/2 (ERK1/2), ERK5 is constitutively activated in Src-transformed fibroblasts. ERK5-deficient cells expressing v-Src exhibited increased RhoA activation and signaling, which lead to cellular retraction and an inability to form podosomes or induce invasion. Addition of the Rho-kinase inhibitor Y27632 to ERK5-deficient cells expressing v-Src led to cellular extension and restored podosome formation. In Src-transformed cells, ERK5 induced the expression of a Rho GTPase-activating protein (RhoGAP), RhoGAP7/DLC-1, via activation of the transcription factor myocyte enhancing factor 2C, and RhoGAP7 expression restored podosome formation in ERK5-deficient cells. We conclude that ERK5 promotes Src-induced podosome formation by inducing RhoGAP7 and thereby limiting Rho activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.