ArticleInfection and immunity2008
The resistance of BALB/cJ mice to Yersinia pestis maps to the major histocompatibility complex of chromosome 17.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Functionally distinct regions of the locusFrontiers in immunology · 2023Article
- Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.The Journal of pharmacology and experimental therapeutics · 2022Article
- Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2Infection and immunity · 2020Article
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.Infection and immunity · 2016Article
- Genetic variation at the MHC DRB1 locus is similar across Gunnison's prairie dog (Cynomys gunnisoni) colonies regardless of plague history.Ecology and evolution · 2016Article
- S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.Immunity · 2014Article
- Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages.Journal of leukocyte biology · 2014Article
- Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine.Clinical and vaccine immunology : CVI · 2013Article
- Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM.Infection and immunity · 2012Article
- Contrasted patterns of selection on MHC-linked microsatellites in natural populations of the Malagasy plague reservoir.PloS one · 2012Article
- Resistance to Yersinia pestis infection decreases with age in B10.T(6R) mice.Infection and immunity · 2011Article
- Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice.Infection and immunity · 2011Article
- The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background.Infection and immunity · 2011Article
- Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control.Genes and immunity · 2011Article
- Model systems to study plague pathogenesis and develop new therapeutics.Frontiers in microbiology · 2010Article
- Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice.Infection and immunity · 2009Article
- Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross.Molecular painArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Yersinia pestis, the causative agent of plague, has been well studied at the molecular and genetic levels, but little is known about the role that host genes play in combating this highly lethal pathogen. We challenged several inbred strains of mice with Y. pestis and found that BALB/cJ mice are highly resistant compared to susceptible strains such as C57BL/6J. This resistance was observed only in BALB/cJ mice and not in other BALB/c substrains. Compared to C57BL/6J mice, the BALB/cJ strain exhibited reduced bacterial burden in the spleen and liver early after infection as well as lower levels of serum interleukin-6. These differences were evident 24 h postinfection and became more pronounced with time. Although a significant influx of neutrophils in the spleen and liver was exhibited in both strains, occlusive fibrinous thrombi resulting in necrosis of the surrounding tissue was observed only in C57BL/6J mice. In an effort to identify the gene(s) responsible for resistance, we measured total splenic bacteria in 95 F(2) mice 48 h postinfection and performed quantitative trait locus mapping using 58 microsatellite markers spaced throughout the genome. This analysis revealed a single nonrecessive plague resistance locus, designated prl1 (plague resistance locus 1), which coincides with the major histocompatibility complex of chromosome 17. A second screen of 95 backcrossed mice verified that this locus confers resistance to Y. pestis early in infection. Finally, eighth generation backcrossed mice harboring prl1 were found to maintain resistance in the susceptible C57BL/6J background. These results identify a novel genetic locus in BALB/cJ mice that confers resistance to Y. pestis.
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