ArticleMolecular and cellular biology2008
Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility.Human reproduction (Oxford, England) · 2018Pooled it
- Prognostic alternative mRNA splicing signature and immune infiltration in prostate cancer.Journal of applied genetics · 2026Article
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- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine.International journal of molecular sciences · 2022Review
- Article
- Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors.Molecular cell · 2015Article
- Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Orchestration of neurodevelopmental programs by RBFOX1: implications for autism spectrum disorder.International review of neurobiology · 2013Review
- Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.RNA (New York, N.Y.) · 2012Article
- Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function.Frontiers in neuroscience · 2012Article
- Fox-3 and PSF interact to activate neural cell-specific alternative splicing.Nucleic acids research · 2011Article
- SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons.Molecular and cellular biology · 2011Article
- Synaptic signaling and aberrant RNA splicing in autism spectrum disorders.Frontiers in synaptic neuroscience · 2011Article
- Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts.Development (Cambridge, England) · 2010Article
- Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members.Nucleic acids research · 2010Article
- HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease.Molecular and cellular biology · 2010Article
- Fox-1 family of RNA-binding proteins.Cellular and molecular life sciences : CMLS · 2009Review
- Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.Nature reviews. Molecular cell biology · 2009Review
- Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Precise and robust regulation of alternative splicing provides cells with an essential means of gene expression control. However, the mechanisms that ensure the tight control of tissue-specific alternative splicing are not well understood. It has been demonstrated that robust regulation often results from the contributions of multiple factors to one particular splicing pathway. We report here a novel strategy used by a single splicing regulator that blocks the formation of two distinct prespliceosome complexes to achieve efficient regulation. Fox-1/Fox-2 proteins, potent regulators of alternative splicing in the heart, skeletal muscle, and brain, repress calcitonin-specific splicing of the calcitonin/CGRP pre-mRNA. Using biochemical analysis, we found that Fox-1/Fox-2 proteins block prespliceosome complex formation at two distinct steps through binding to two functionally important UGCAUG elements. First, Fox-1/Fox-2 proteins bind to the intronic site to inhibit SF1-dependent E' complex formation. Second, these proteins bind to the exonic site to block the transition of E' complex that escaped the control of the intronic site to E complex. These studies provide evidence for the first example of regulated E' complex formation. The two-step repression of presplicing complexes by a single regulator provides a powerful and accurate regulatory strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.