ArticleMolecular and cellular biology2008
Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation.Nucleic acids research · 2025Article
- The PBAP chromatin remodeling complex mediates summer diapause via H3K4me3-driven juvenile hormone regulation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional Role of Bap170 Domains in Enhancer-Dependent Gene Activity in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2025Article
- The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.BMC biology · 2023Article
- Kinetic principles underlying pioneer function of GAGA transcription factor in live cells.Nature structural & molecular biology · 2022Article
- Chromatin-Remodelling ATPasesInternational journal of molecular sciences · 2022Article
- Enhancer analysis of the Drosophila zinc finger transcription factor Earmuff by gene targeting.Hereditas · 2021Article
- Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription inInternational journal of molecular sciences · 2021Article
- Regulation of growth and cell fate during tissue regeneration by the two SWI/SNF chromatin-remodeling complexes of Drosophila.Genetics · 2021Article
- Unwinding chromatin at the right places: how BAF is targeted to specific genomic locations during development.Development (Cambridge, England) · 2019Review
- Pleiotropic Functions of the Chromodomain-Containing Protein Hat-trick During Oogenesis inG3 (Bethesda, Md.) · 2018Article
- Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice.Nature microbiology · 2017Article
- Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequences.Nature communications · 2016Article
- Drosophila Brahma complex remodels nucleosome organizations in multiple aspects.Nucleic acids research · 2014Article
- Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.G3 (Bethesda, Md.) · 2014Article
- Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors.Development (Cambridge, England) · 2014Article
- Evidence for chromatin-remodeling complex PBAP-controlled maintenance of the Drosophila ovarian germline stem cells.PloS one · 2014Article
- Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.eLife · 2013Article
- The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Nucleic acids research · 2012Article
- ATP-dependent chromatin remodeling in T cells.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin remodeling complexes control the availability of DNA binding sites to transcriptional regulators. Two distinct conserved forms of the SWI/SNF class of complexes are characterized by the presence of specific accessory subunits. In Drosophila, the core Brahma complex associates either with Osa to form the BAP complex or with Bap170 and Bap180 to form the PBAP complex. osa mutations reproduce only a subset of the developmental phenotypes caused by mutations in subunits of the core complex. To test whether the PBAP complex performs the remaining functions, we generated mutations in bap170 and bap180. Surprisingly, we found that Bap180 is not essential for viability, although it is required in ovarian follicle cells for normal eggshell development. Bap170 is necessary to stabilize the Bap180 protein, but a mutant form that retains this function is sufficient for both survival and fertility. The two subunits act redundantly to allow metamorphosis; using gene expression profiling of bap170 bap180 double mutants, we found that the PBAP complex regulates genes involved in tissue remodeling and immune system function. Finally, we generated mutants lacking Bap170, Bap180, and Osa in the germ line to demonstrate that the core Brahma complex can function in oogenesis without any of these accessory subunits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.