ArticleAtherosclerosis2009
IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study.
Article in Atherosclerosis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Translational Metabolomics: Current Challenges and Future Opportunities.Metabolites · 2019Article
- Cytokine polymorphisms are associated with daytime napping in adults living with HIV.Sleep medicine · 2017Article
- Genetic variants in genes of the inflammatory response in association with infective endocarditis.PloS one · 2014Article
- Cardiovascular genomics: a biomarker identification pipeline.IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society · 2012Review
- Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2009Article
- The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk.Current atherosclerosis reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveInterleukin-1B (IL1B) modulates C-reactive protein (CRP) expression. However, whether IL1B genetic variation is associated with CRP level is unknown. Further, obesity, a state of low-grade inflammation that influences cellular IL-1 functions may modify this association. METHODS AND
resultsStudy participants (N=3289), 48% blacks and 52% whites, had CRP level measurements at year 7 and year 15 examinations as part of the CARDIA study. Ten tag single nucleotide polymorphisms (SNPs) that characterize common IL1B gene variation were genotyped. In SNP analysis, no significant associations with either level or change in time CRP were observed after multiple testing adjustments. However, global ILIB gene variation was associated with year 7 to year 15 change in CRP (global nominal p=0.004, multiple testing corrected p=0.048) among obese blacks. Compared to the commonest haplotype, a common haplotype that includes the SNP rs1143642 was associated with greater increases in CRP from year 7 to year 15 among obese blacks and whites while another common haplotype that includes the SNP rs3917356 was associated with decreased change in CRP from year 7 to year 15 among obese blacks. The rare alleles of ILIB SNPs, SNP 7114 (rs1143642) and SNP 3298 (rs3917356), were associated with greater increases and decreases in CRP from year 7 to year 15 among blacks, respectively, compared to their common variants.
conclusionIL1B genetic variation may have a role in CRP level regulation and this association may be modified by obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.