ArticleMolecular microbiology2008
A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- RNAP-seq:bioRxiv : the preprint server for biology · 2026Article
- Cell-free genomics reveals fundamental regulatory principles of the Mycobacterium tuberculosis transcription cycle.Molecular cell · 2026Article
- Systematic modulation of bacterial resource allocation by perturbing RNA polymerase availability via synthetic transcriptional switches.Nucleic acids research · 2025Article
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- Characterization of Bacterial Transcriptional Regulatory Networks inMicroorganisms · 2023Article
- Oxalate decarboxylase uses electron hole hopping for catalysis.The Journal of biological chemistry · 2021Article
- Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis.PLoS genetics · 2021Article
- The pneumococcal σThe Journal of biological chemistry · 2019Article
- Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems.Molecular microbiology · 2017Article
- Characterization of a protein-protein interaction within the SigO-RsoA two-subunit σ factor: the σ70 region 2.3-like segment of RsoA mediates interaction with SigO.Microbiology (Reading, England) · 2016Article
- Promoter Escape with Bacterial Two-component σ Factor Suggests Retention of σ Region Two in the Elongation Complex.The Journal of biological chemistry · 2015Article
- Article
- Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain.MicrobiologyOpen · 2012Article
- Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance.Nucleic acids research · 2012Article
- The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics.Journal of bacteriology · 2011Article
- Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis.Antimicrobial agents and chemotherapy · 2011Article
- Evolution of multisubunit RNA polymerases in the three domains of life.Nature reviews. Microbiology · 2011Review
- A two-subunit bacterial sigma-factor activates transcription in Bacillus subtilis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein.Molecular microbiology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the function of a cell envelope stress-inducible gene, yvrI, which encodes a 22.5 kDa protein that includes a predicted sigma(70) region 4 domain, but lacks an apparent region 2 domain. YvrI interacts with RNA polymerase and overexpression of YvrI results in induction of OxdC, an oxalate decarboxylase maximally expressed under low-pH conditions. We have used microarray-based analyses to define the YvrI regulon. YvrI is required for the transcription of three operons (oxdC-yvrL, yvrJ and yvrI-yvrHa) each of which is preceded by a highly similar promoter sequence. Activation of these promoters requires both YvrI and the product of the second gene in the yvrI-yvrHa operon, YvrHa. YvrI and YvrHa together allow recognition of the oxdC promoter, stimulate DNA melting and activate transcription by core RNA polymerase. Together, these results suggest that YvrI is a previously unrecognized sigma factor in Bacillus subtilis and that the 9.5 kDa YvrHa protein acts as a required co-activator of transcription. A yvrL deletion results in the upregulation of YvrI activity suggesting that YvrL is a negative regulator of YvrI-dependent transcription, possibly functioning as an anti-sigma factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.