ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2008
Fatigue in patients receiving maintenance dialysis: a review of definitions, measures, and contributing factors.
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
131 citing papers in PubMed, 5 syntheses or guidelines pooled it, 349 citations in OpenAlex.
- Comparative efficacy of non-pharmacological interventions on fatigue in people undergoing hemodialysis: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023Pooled it
- Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022Pooled it
- Fatigue in incident peritoneal dialysis and mortality: A real-world side-by-side study in Brazil and the United States.PloS one · 2022Pooled it
- Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Cluster analysis-based classification of fatigue in stable maintenance hemodialysis patients: a prospective cohort study.Journal of nephrology · 2024Trial
- A randomized controlled pilot trial of anakinra for hemodialysis inflammation.Kidney international · 2022Trial
- Trial
- Trial
- Protocol of a mixed method, randomized controlled study to assess the efficacy of a psychosocial intervention to reduce fatigue in patients with End-Stage Renal Disease (ESRD).BMC nephrology · 2016Trial
- Treating hypertension in hemodialysis improves symptoms seemingly unrelated to volume excess.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Trial
- Ecological momentary assessment of fatigue, sleepiness, and exhaustion in ESKD.BMC nephrology · 2014Trial
- Effects of 6-times-weekly versus 3-times-weekly hemodialysis on depressive symptoms and self-reported mental health: Frequent Hemodialysis Network (FHN) Trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Trial
- Factors Associated With Weight Management Referral Acceptance and Uptake in Kidney Transplant Candidates.Clinical transplantation · 2026Article
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Article
- A combined progressive muscle relaxation and walking intervention for adults with end-stage kidney disease receiving hemodialysis (Contemporary clinical trials communications · 2026Article
- Post-Dialysis Syndrome: A Narrative Review.Kidney360 · 2026Review
- Development and validation of a physical fatigue assessment scale for patients undergoing maintenance hemodialysis.BMC nephrology · 2026Article
- Anxiety, Social Support and Coping Strategies in Patients Undergoing Maintenance Haemodialysis.Nursing open · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Fatigue is a debilitating symptom or side effect experienced by many patients on long-term dialysis therapy. Fatigue has a considerable effect on patient health-related quality of life and is viewed as being more important than survival by some patients. Renal providers face many challenges when attempting to reduce fatigue in dialysis patients. The lack of a reliable, valid, and sensitive fatigue scale complicates the accurate identification of this symptom. Symptoms of daytime sleepiness and depression overlap with fatigue, making it difficult to target specific therapies. Moreover, many chronic health conditions common in the long-term dialysis population may lead to the development of fatigue and contribute to the day-to-day and diurnal variation in fatigue in patients. Key to improving the assessment and treatment of fatigue is improving our understanding of potential mediators, as well as potential therapies. Cytokines have emerged as an important mediator of fatigue and have been studied extensively in patients with cancer-related fatigue. In addition, although erythropoietin-stimulating agents have been shown to mitigate fatigue, the recent controversy regarding erythropoietin-stimulating agent dosing in patients with chronic kidney disease suggests that erythropoietin-stimulating agent therapy may not serve as the sole therapy to improve fatigue in this population. In conclusion, fatigue is an important and often underrecognized symptom in the dialysis population. Possible interventions for minimizing fatigue in patients on long-term dialysis therapy should aim at improving health care provider awareness, developing improved methods of measurement, understanding the pathogenesis better, and managing known contributing factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.