Trial reportThe American journal of cardiology2008
Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women.
Trial report in The American journal of cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01173380 (Effects of Soy on Metabolite Markers of Health), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Soy on Metabolite Markers of Health
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Can soy isoflavones in combination with soy protein change serum levels of C-reactive protein among patients with chronic inflammatory diseases? A systematic review and meta-analysis on randomized controlled trials.Journal of health, population, and nutrition · 2025Pooled it
- Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials.European journal of nutrition · 2021Pooled it
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017.Journal of atherosclerosis and thrombosis · 2018Guideline
- Association of vegetarian diet with inflammatory biomarkers: a systematic review and meta-analysis of observational studies.Public health nutrition · 2017Pooled it
- Effect of soy nuts and equol status on blood pressure, lipids and inflammation in postmenopausal women stratified by metabolic syndrome status.Metabolism: clinical and experimental · 2015Trial
- Soy provides modest benefits on endothelial function without affecting inflammatory biomarkers in adults at cardiometabolic risk.Molecular nutrition & food research · 2015Trial
- Heterogeneous vascular responses to lifestyle intervention in obese Latino adolescents.Metabolic syndrome and related disorders · 2014Trial
- Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial.Nutrition research (New York, N.Y.) · 2013Trial
- Soy milk consumption, inflammation, coagulation, and oxidative stress among type 2 diabetic patients with nephropathy.Diabetes care · 2012Trial
- The Effect of Dietary Pattern on Metabolic Syndrome in a Suburban Population in Shanghai, China.Nutrients · 2023Article
- Genistein in the Treatment of Hypertension: A Review.Endocrine, metabolic & immune disorders drug targets · 2022Review
- Effects of soy consumption on metabolic parameters in patients with metabolic syndrome: A systematic review and meta-analysis.EXCLI journal · 2021Article
- Isoflavones: Anti-Inflammatory Benefit and Possible Caveats.Nutrients · 2016Review
- The role of nutrition and nutraceutical supplements in the treatment of hypertension.World journal of cardiology · 2014Review
- Influence of physical activity and nutrition on obesity-related immune function.TheScientificWorldJournal · 2013Review
- Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats.European journal of nutrition · 2013Article
- Effect of Soymilk Consumption on Waist Circumference and Cardiovascular Risks among Overweight and Obese Female Adults.International journal of preventive medicine · 2012Article
- A modified sesamol derivative inhibits progression of atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis).American journal of primatology · 2009Review
- Inflammatory markers in a 2-year soy intervention among premenopausal women.Journal of inflammation (London, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recently, it was shown that substituting soy nuts for nonsoy protein in a therapeutic lifestyle change (TLC) diet lowered systolic and diastolic blood pressure by 9.9% and 6.8%, respectively, in postmenopausal women with hypertension and by 5.2% and 2.9%, respectively, in normotensive postmenopausal women. In this study, to examine mechanisms for these reductions, markers of inflammation were measured, including soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, C-reactive protein, interleukin-6, and matrix metalloproteinase-9. Sixty healthy postmenopausal women (48 normotensive and 12 with hypertension) were randomized in a crossover design to a TLC diet alone or a TLC diet in which 0.5 cups of soy nuts (25 g soy protein and 101 mg aglycone isoflavones) replaced 25 g of nonsoy protein daily. Each diet was followed for 8 weeks. Compared with the TLC diet alone, levels of soluble vascular cell adhesion molecule-1 were significantly lower on the soy diet in women with hypertension (623.6 +/- 153.8 vs 553.8 +/- 114.4 ng/ml, respectively, p = 0.003), whereas no significant differences were observed in normotensive women. Soy nuts were associated with a trend toward reduction in C-reactive protein in normotensive women. No effect on levels of soluble intercellular adhesion molecule-1, interleukin-6, or matrix metalloproteinase-9 was observed. In conclusion, the reduction in soluble vascular cell adhesion molecule-1 with soy nuts in women with hypertension suggests an improvement in endothelial function that may reflect an overall improvement in the underlying inflammatory process underlying atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.