Evidence map›Paper›PMID 18571629›Full record

SynthesisBiological psychiatry2008

Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.

Srijan Sen, Ronald Duman, Gerard Sanacora

2 registry-linked trialsOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 484 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
484citing papers in PubMed, 10 pooled it
25.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01805479 nawithdrawnnot on this mapstarted 2013, after this paper: background citation

Exercise Training in Depressed Traumatic Brain Injury Survivors

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2013 to 2014Enrolled0ConditionsDepression, Traumatic Brain InjuryArmsaerobic exercise, stretching and flexibility program
NCT02495194 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Effects of Horticultural Therapy on Asian Elderly' Mental Health: A Randomized Controlled Trial

TypeinterventionalSponsorNational University of SingaporeRan2015 to 2016Enrolled69ConditionsMood (Psychological Function)ArmsHorticultural Therapy
3 · Its place in the literature

Who cites it

484 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,213 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

424 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Srijan SenDepartment of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06519, USA.
Ronald Duman
Gerard Sanacora
Yale University · US

Funding

SCHIZOPHRENIAP01MH025642 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1985 to 2006
$8.4M
Antidepressants: Signal Transduction and Gene ExpressionR37MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 2005 to 2014
$3.5M
ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAINR01MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1995 to 2004
$1.3M
Studies of Amino Acid Neurotransmitter Contributions to DepressionK02MH076222 · NIMH · YALE UNIVERSITY · PI SANACORA, GERARD · 2006 to 2010
$634k
ANTIDEPRESSANTS: SIGNAL TRANSDUCTION AND GENE EXPRESSIONR29MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1989 to 1993
–
NIMH NIH HHS K02 MH076222NIMH NIH HHS K02 MH076222-01NIMH NIH HHS MH025642NIMH NIH HHS MH045481NIMH NIH HHS P01 MH025642NIMH NIH HHS R01 MH045481NIMH NIH HHS R37 MH045481
6 · The paper itself

Abstract

backgroundConverging lines of evidence implicate the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent studies have begun to explore the relationship between serum BDNF and depression.

methodsWe conducted meta-analyses of 11 studies examining differences in serum BDNF content between depressed and nondepressed subjects (N = 748), and eight studies comparing pre- and post-antidepressant treatment serum BDNF content (N = 220).

resultsThe meta-analysis revealed strong evidence that BDNF levels were lower in depressed subjects than healthy control subjects (p < 6.8 x 10(-8)). Similarly, the second meta-analysis found significantly higher BDNF levels after antidepressant treatment (p = .003). There was no evidence of publication bias in the first (p = .376) or second (p = .571) meta-analysis and no evidence that either meta-analysis was unduly influenced by any one study.

conclusionsThese findings provide strong evidence to suggest that serum BDNF levels are abnormally low in patients suffering from major depressive disorder and that the BDNF levels are elevated following a course of antidepressant treatment. Although the relationship of our findings to pathophysiology of depression and the mechanism of drug action remains to be determined, the measure may have potential use as a biomarker for psychiatric disorders or as a predictor of antidepressant efficacy.

Indexed as

AdultAntidepressive AgentsBrain-Derived Neurotrophic FactorFemaleHumansMajor Depressive DisorderMaleMiddle AgedAntidepressive AgentsBrain-Derived Neurotrophic Factor

Identifiers

PMID18571629
PMCPMC2597158
OpenAlexW2043283741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.