Evidence map›Paper›PMID 18571265›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2008

Recent progress in tumor pH targeting nanotechnology.

Eun Seong Lee, Zhonggao Gao, You Han Bae

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed.

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  13. Anti-Colorectal Cancer Activity ofInternational journal of molecular sciences · 2025
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eun Seong LeeDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, 421 Wakara Way, Suite 315, Utah 84108, USA.
Zhonggao Gao
You Han Bae

Funding

ENGINEERED INTELLIGENT MICELLE FOR TUMOR pH TARGETINGR01CA101850 · NCI · UNIVERSITY OF UTAH · PI BAE, YOU HAN · 2004 to 2013
$2.4M
Micelle surface engineering for active targeting by acidic tumor extracellular pHR01CA122356 · NCI · UNIVERSITY OF UTAH · PI BAE, YOU HAN · 2006 to 2010
$1.3M
NCI NIH HHS CA101850NCI NIH HHS CA122356NCI NIH HHS R01 CA101850NCI NIH HHS R01 CA122356
6 · The paper itself

Abstract

pH-sensitive polymeric micelles and nanogels have recently been developed to target slightly acidic extracellular pH environment of solid tumors. The pH targeting approach is regarded as a more general strategy than conventional specific tumor cell surface targeting approaches, because the acidic tumor microclimate is most common in solid tumors. When nanosystems are combined with triggered release mechanisms by endosomal or lysosomal acidity plus endosomolytic capability, the nanocarriers demonstrated to overcome multidrug resistance of various tumors. This review highlights recent progress of the pH-sensitive nanotechnology developed in Bae research group.

Indexed as

Drug CarriersNanoparticlesAnimalsAntineoplastic AgentsChemistry, PharmaceuticalDelayed-Action PreparationsDrug Resistance, NeoplasmEndocytosisEndosomesGelsHumansHydrogen-Ion ConcentrationLysosomesMicellesNeoplasmsPolymersAntineoplastic AgentsDelayed-Action PreparationsDrug CarriersGelsMicellesPolymers

Identifiers

PMID18571265
PMCPMC2695946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.