ArticlePharmacology, biochemistry, and behavior2008
Ethanol-mediated operant learning in the infant rat leads to increased ethanol intake during adolescence.
Article in Pharmacology, biochemistry, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response.Alcohol (Fayetteville, N.Y.) · 2016Article
- Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose.Alcohol (Fayetteville, N.Y.) · 2014Article
- Prenatal exposure to ethanol during late gestation facilitates operant self-administration of the drug in 5-day-old rats.Alcohol (Fayetteville, N.Y.) · 2014Article
- Prenatal ethanol exposure increases ethanol intake and reduces c-Fos expression in infralimbic cortex of adolescent rats.Pharmacology, biochemistry, and behavior · 2013Article
- Role of mu, delta and kappa opioid receptors in ethanol-reinforced operant responding in infant rats.Behavioural brain research · 2012Article
- Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement.Alcohol (Fayetteville, N.Y.) · 2012Article
- Ontogenetic differences in ethanol's motivational properties during infancy.Alcohol (Fayetteville, N.Y.) · 2012Article
- Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm.Psychopharmacology · 2012Article
- Ontogeny of ethanol intake in alcohol preferring (P) and alcohol nonpreferring (NP) rats.Developmental psychobiology · 2011Article
- High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence.Developmental psychobiology · 2010Article
- Genetic and environmental influences on ethanol consumption: perspectives from preclinical research.Alcoholism, clinical and experimental research · 2010Review
- Assessing appetitive, aversive, and negative ethanol-mediated reinforcement through an immature rat model.Neuroscience and biobehavioral reviews · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies indicate that the infant rat has high affinity for ethanol ingestion and marked sensitivity to the drug's reinforcing effects [Spear, N.E., Molina, J.C. Fetal or infantile exposure to ethanol promotes ethanol ingestion in adolescence and adulthood: a theoretical review. Alcohol Clin Exp Res 2005; 29: 909-29.]. A novel operant technique was developed to analyze reinforcing effects of ethanol delivery during the third postnatal week. The impact of this ethanol-reinforcement experience upon subsequent ethanol consumption during adolescence (postnatal weeks 5-6) was also examined. In Experiment 1, pups (postnatal days 14-17) were given an explicit contingency between nose-poking behavior and intraoral delivery of either water or 3.75% v/v ethanol (paired groups). Yoked controls (pups receiving either reinforcer independently of their behavior) were also included. Paired subjects reinforced with ethanol exhibited rapid and robust operant conditioning leading to blood ethanol concentrations in the 25-48 mg% range. In Experiment 2, a higher ethanol concentration (7.5% v/v) provided significant reinforcement. During adolescence, animals originally reinforced with 3.75% v/v ethanol exhibited greater ingestion of ethanol than control animals without prior ethanol reinforcement. These results indicate that, without extensive initiation to ethanol, infant rats rapidly learn to gain access to ethanol and that this experience has a significant impact upon later ethanol intake patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.