ArticleAmerican journal of human genetics2008
Positive selection in alternatively spliced exons of human genes.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Recurrent erosion of COA1/MITRAC15 exemplifies conditional gene dispensability in oxidative phosphorylation.Scientific reports · 2021Article
- Defining the genetic and evolutionary architecture of alternative splicing in response to infection.Nature communications · 2019Article
- Mutational bias is the driving force for shaping the synonymous codon usage pattern of alternatively spliced genes in rice (Oryza sativa L.).Molecular genetics and genomics : MGG · 2015Article
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- Evolutionary dynamics of human autoimmune disease genes and malfunctioned immunological genes.BMC evolutionary biology · 2012Article
- Genome-wide evidence for selection acting on single amino acid repeats.Genome research · 2010Article
- Rodent-specific alternative exons are more frequent in rapidly evolving genes and in paralogs.BMC evolutionary biology · 2009Article
- Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.Malaria journal · 2009Article
- Evolution of alternative and constitutive regions of mammalian 5'UTRs.BMC genomics · 2009Article
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Authors and funding
5 authors.
Funding
Abstract
Alternative splicing is a well-recognized mechanism of accelerated genome evolution. We have studied single-nucleotide polymorphisms and human-chimpanzee divergence in the exons of 6672 alternatively spliced human genes, with the aim of understanding the forces driving the evolution of alternatively spliced sequences. Here, we show that alternatively spliced exons and exon fragments (alternative exons) from minor isoforms experience lower selective pressure at the amino acid level, accompanied by selection against synonymous sequence variation. The results of the McDonald-Kreitman test suggest that alternatively spliced exons, unlike exons constitutively included in the mRNA, are also subject to positive selection, with up to 27% of amino acids fixed by positive selection.
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