ArticleGenome biology2008
Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.Virulence · 2023Review
- Article
- Population genomics reveals the origin and asexual evolution of human infective trypanosomes.eLife · 2016Article
- Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon.Parasites & vectors · 2014Article
- A call to arms: on refining Plasmodium vivax microsatellite marker panels for comparing global diversity.Malaria journal · 2013Article
- Article
- Genetic characterization of Trichomonas vaginalis isolates by use of multilocus sequence typing.Journal of clinical microbiology · 2012Article
- Evidence for widespread GC-biased gene conversion in eukaryotes.Genome biology and evolution · 2012Article
- Sexual recombination is a signature of a persisting malaria epidemic in Peru.Malaria journal · 2011Article
- Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1.PLoS neglected tropical diseases · 2011Article
- Microsatellite polymorphism in the sexually transmitted human pathogen Trichomonas vaginalis indicates a genetically diverse parasite.Molecular and biochemical parasitology · 2011Article
- Evolution of eukaryotic microbial pathogens via covert sexual reproduction.Cell host & microbe · 2010Review
- An infectious topic in reticulate evolution: introgression and hybridization in animal parasites.Genes · 2010Article
- A major genetic locus in Trypanosoma brucei is a determinant of host pathology.PLoS neglected tropical diseases · 2009Article
- Genomic linkage map of the human blood fluke Schistosoma mansoni.Genome biology · 2009Article
- Genetics and genomics converge on the human blood fluke.Genome biology · 2009Review
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7 authors.
Funding
Abstract
backgroundTrypanosoma brucei is the causative agent of human sleeping sickness and animal trypanosomiasis in sub-Saharan Africa, and it has been subdivided into three subspecies: Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause sleeping sickness in humans, and the nonhuman infective Trypanosoma brucei brucei. T. b. gambiense is the most clinically relevant subspecies, being responsible for more than 90% of all trypanosomal disease in humans. The genome sequence is now available, and a Mendelian genetic system has been demonstrated in T. brucei, facilitating genetic analysis in this diploid protozoan parasite. As an essential step toward identifying loci that determine important traits in the human-infective subspecies, we report the construction of a high-resolution genetic map of the STIB 386 strain of T. b. gambiense.
resultsThe genetic map was determined using 119 microsatellite markers assigned to the 11 megabase chromosomes. The total genetic map length of the linkage groups was 733.1 cM, covering a physical distance of 17.9 megabases with an average map unit size of 24 kilobases/cM. Forty-seven markers in this map were also used in a genetic map of the nonhuman infective T. b. brucei subspecies, permitting comparison of the two maps and showing that synteny is conserved between the two subspecies.
conclusionThe genetic linkage map presented here is the first available for the human-infective trypanosome T. b. gambiense. In combination with the genome sequence, this opens up the possibility of using genetic analysis to identify the loci responsible for T. b. gambiense specific traits such as human infectivity as well as comparative studies of parasite field populations.
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