ArticleViral immunology2008
Hepatitis C virus core protein discriminates between the two IgG2 allotypes.
Article in Viral immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Beyond Allotypes: The Influence of Allelic Diversity in Antibody Constant Domains.Frontiers in immunology · 2020Review
- The forgotten tale of immunoglobulin allotypes in cancer risk and treatment.Experimental hematology & oncology · 2013Article
- Genetic markers of IgG influence the outcome of infection with hepatitis C virus.The Journal of infectious diseases · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Immunoglobulin GM allotypes, genetic markers of IgG, are associated with the outcome of hepatitis C virus (HCV) infection, but the underlying mechanisms are not completely understood. HCV has evolved mechanisms for decreasing the efficacy of the host immune response. One such strategy might involve the scavenging of the Fcgamma domain of the anti-HCV IgG antibodies by its Fcgamma -receptor-like core protein and thus interfering with the Fcgamma -mediated host defense mechanisms. We tested the hypothesis that GM allotypes modulate this viral strategy through differential binding to the core protein. Here we show that the absorbance values for binding to the core protein were higher for GM23+IgG2 than for GM23-IgG2 (p = 0.027), a finding that at least in part explains the involvement of GM allotypes in the outcome of HCV infection. These findings also contribute toward our understanding of the mechanisms that maintain strong linkage disequilibrium between particular GM alleles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.