ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Vigorous physical activity increases fracture risk in children irrespective of bone mass: a prospective study of the independent risk factors for fractures in healthy children.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02805647 (Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures), which is not on this map. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- What is the association between physical activity and fracture risk in middle-aged adults (aged 30-60): a systematic review and synthesis without meta-analysis (SWIM).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Physical activity and prospective associations with indicators of health and development in children aged <5 years: a systematic review.The international journal of behavioral nutrition and physical activity · 2021Pooled it
- Systematic review of the relationships between physical activity and health indicators in the early years (0-4 years).BMC public health · 2017Pooled it
- The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Pooled it
- Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Fracture Incidence With 6-9 Years of Daily School Physical Activity: Lower Relative Fracture Risk at the End of the Intervention But Not After.Scandinavian journal of medicine & science in sports · 2026Article
- Association between drinking water hardness and incidence of hospitalization for childhood fracture: an ecological study of England.JBMR plus · 2026Article
- Global, regional, and national burdens of fracture in children and adolescents from 1990 to 2019.BMC public health · 2025Article
- Epidemiological features and injury patterns of multiple fractures in children: a cross-sectional study.Frontiers in public health · 2025Article
- Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta.Calcified tissue international · 2024Review
- Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023Review
- Epidemiological Investigation of Pediatric Fractures-A Retrospective Cohort Study of 1129 Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Decreased bone mass in adolescents with bone fragility fracture but not in young children: a case-control study.Frontiers in endocrinology · 2023Article
- Is repeated childhood fracture related to areal bone density or body composition in middle age?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Risk factors for upper limb fractures due to unintentional injuries among adolescents: a case control study from Sri Lanka.BMC public health · 2022Article
- Levels of Physical Activity in Children with Extremity Fractures a Dutch Observational Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Bone mineral density and oxidative stress in adolescent girls with anorexia nervosa.European journal of pediatrics · 2022Article
- The incidence of distal radius fractures in a Swedish pediatric population - an observational cohort study of 90 970 individual fractures.BMC musculoskeletal disorders · 2021Observational
- Childhood Distal Forearm Fracture Incidence in Malmö, Sweden 1950 to 2016.Journal of wrist surgery · 2021Article
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Low bone mass is a determinant of fractures in healthy children. Small studies provide limited evidence on the association between ethnicity, birth weight, family size, socioeconomic status, dietary calcium intake, or physical activity and fracture incidence. No studies have investigated whether these determinants of fracture risk act through affecting bone mass or through other mechanisms. The aim of this study was to use a population-based birth cohort to confirm which variables are determinants of fracture risk and to further study which of these risk factors act independently of bone mass. Children from the Avon Longitudinal Study of Parents and Children have been followed up from birth to 11 yr of age. Maternal self-reported data have been collected contemporaneously on early life factors, diet, puberty, and physical activity. These were linked to reported fractures between 9 and 11 yr of age. Multivariable logistic regression techniques were used to assess whether these potential determinants were independent of, or worked through, estimated volumetric BMD or estimated bone size relative to body size measured by total body DXA scan at 9.9 yr of age. A total of 2692 children had full data. One hundred ninety-three (7.2%) reported at least one fracture over the 2-yr follow-up period. Children who reported daily or more episodes of vigorous physical activity had double the fracture risk compared with those children who reported less than four episodes per week (OR, 2.06; 95% CI, 1.21-1.76). No other independent determinants of fracture risk in healthy children were found. In conclusion, reported vigorous physical activity is an independent risk factor for childhood fracture risk. However, the interrelationship between physical activity, bone mass, and childhood fracture risk suggests that the higher bone mass associated with increased physical activity does not compensate for the risk caused by increased exposure to injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.