ArticleJournal of investigative surgery : the official journal of the Academy of Surgical Research
Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure.
Article in Journal of investigative surgery : the official journal of the Academy of Surgical Research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Blood-brain barrier dysfunction in hepatic encephalopathy: pathophysiology, diagnostic assessment and therapeutic perspectives.Metabolic brain disease · 2025Review
- The neurogliovascular unit in hepatic encephalopathy.JHEP reports : innovation in hepatology · 2021Review
- The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure.International journal of molecular sciences · 2020Article
- Cerebral edema and liver disease: Classic perspectives and contemporary hypotheses on mechanism.Neuroscience letters · 2020Review
- Direct Comparison of the Thioacetamide and Azoxymethane Models of Type A Hepatic Encephalopathy in Mice.Gene expression · 2018Article
- Blood-Brain Barrier Permeability Is Exacerbated in Experimental Model of Hepatic Encephalopathy via MMP-9 Activation and Downregulation of Tight Junction Proteins.Molecular neurobiology · 2018Article
- Lipopolysaccharide-Induced Striatal Nitrosative Stress and Impaired Social Recognition Memory Are Not Magnified by Paraquat Coexposure.Neurochemical research · 2018Article
- Annexin A1 restores AβAging cell · 2017Article
- Recent advances in hepatic encephalopathy.F1000Research · 2017Review
- Gene Expression Changes in Long-Term In Vitro Human Blood-Brain Barrier Models and Their Dependence on a Transwell Scaffold Material.Journal of healthcare engineering · 2017Article
- Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure.The American journal of pathology · 2016Article
- TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- The liver-brain axis in liver failure: neuroinflammation and encephalopathy.Nature reviews. Gastroenterology & hepatology · 2013Review
- Brain edema in acute liver failure: role of neurosteroids.Archives of biochemistry and biophysics · 2013Article
- TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Blood-brain barrier in acute liver failure.Neurochemistry international · 2012Review
- Fulminant liver failure model with hepatic encephalopathy in the mouse.Annals of gastroenterology · 2011Article
- TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress.American journal of physiology. Cell physiology · 2010Article
- An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.World journal of gastroenterology · 2009Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Brain edema secondary to increased blood-brain barrier (BBB) permeability is a lethal complication in fulminant hepatic failure (FHF). Intact tight junctions (TJ) between brain capillary endothelial cells are critical for normal BBB function. However, the role of TJ in FHF has not been explored. We hypothesized that alterations in the composition of TJ proteins would result in increased BBB permeability in FHF. In this study, FHF was induced in C57BL/6J mice by using azoxymethane. BBB permeability was assessed with sodium fluorescein. Expression of TJ proteins was determined by Western blot, and their cellular distribution was examined using immunofluorescent microscopy. Comatose FHF mice had significant cerebral sodium fluorescein extravasation compared with control and precoma FHF mice, indicating increased BBB permeability. Western blot analysis showed a significant decrease in zonula occludens (ZO)-2 expression starting in the precoma stage. Immunofluorescent microscopy showed a significantly altered distribution pattern of ZO-2 in isolated microvessels from precoma FHF mice. These changes were more prominent in comatose FHF animals. Significant alterations in ZO-2 expression and distribution in the tight junctions preceded the increased BBB permeability in FHF mice. These results suggest that ZO-2 may play an important role in the pathogenesis of brain edema in FHF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.