ArticleEndocrine pathology2008
Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas.
Article in Endocrine pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Gene expression in prolactinomas: a systematic review.Pituitary · 2016Pooled it
- Lateral one-third gland resection in Cushing patients with failed adenoma identification leads to low remission rates: long-term observations from a small, single-center cohort.Acta neurochirurgica · 2021Article
- ACTH-producing tumorlets and carcinoids of the lung: clinico-pathologic study of 63 cases and review of the literature.Virchows Archiv : an international journal of pathology · 2019Review
- Imatinib Inhibits GH Secretion From Somatotropinomas.Frontiers in endocrinology · 2018Article
- Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis.Stem cell reports · 2013Article
- The study of CD117 expression in glial tumors and its relationship with the tumor-type and grade.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- KIT protein expression and mutational status of KIT gene in pituitary adenomas.Virchows Archiv : an international journal of pathology · 2012Article
- Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway.Endocrine pathology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-kit (CD117) is a tyrosine kinase receptor involved in the proliferation, differentiation, and secretory functions of various cells. In experimental animal models, c-kit has been detected in the pars intermedia of the normal pituitary gland and in alpha-melanocyte-stimulating-hormone-positive adenomas and it has been suggested that it plays a role in regulating adrenocorticotropic hormone (ACTH) secretion. To the best of our knowledge, the expression of c-kit in normal human pituitary cells and in pituitary adenomas has never been reported, so the possible biological role of this receptor in the control of pituitary hormone secretion remains unclear. The aim of this study was to evaluate the immunohistochemical expression of c-kit in normal human pituitary glands and in a series of 62 well-characterized pituitary adenomas. In normal adenohypophyses, several cells, mainly located in the central mucoid wedge, showed a c-kit immunoreactivity (IR). Double label immunostaining procedures showed that the c-kit-IR cells corresponded to ACTH cells. Out of 62 adenomas, 15 (24%) were c-kit-IR, including 7/16 (44%) ACTH cell, 3/7 (42%) null cell, 4/11 (36%) alpha-subunit cell, and 1/11 (10%) follicle-stimulating hormone-luteinizing hormone cell adenomas. By contrast, all ten prolactin cell and seven growth hormone cell adenomas were c-kit negative. These data suggest that, in normal conditions, c-kit may be involved in the pituitary-adrenal axis regulation.
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