ArticlePlant physiology2008
Arginase-negative mutants of Arabidopsis exhibit increased nitric oxide signaling in root development.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 192 citations in OpenAlex.
- Alterations in Arginase Activity and Polyamine Metabolism Contribute to the Mode of Action of Canavanine in Tomato Roots.Biology · 2026Article
- Effects of Roughage Combinations of Sugarcane Dry Leaves and Peanut Vine on the Rumen Microbial Community and Metabolites of Weaned Buffalo Calves.Microorganisms · 2026Article
- Genome-wide association study (GWAS) provides insights into the genomic basis of reproduction-related traits in Chouardia litardierei (Asparagaceae).BMC plant biology · 2025Article
- Nitric oxide-mediated thermomemory: a new perspective on plant heat stress resilience.Frontiers in plant science · 2025Review
- Article
- Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.International journal of molecular sciences · 2024Article
- Different reactions of wheat, maize, and rice plants to putrescine treatment.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Amino Acids Biostimulants and Protein Hydrolysates in Agricultural Sciences.Plants (Basel, Switzerland) · 2024Review
- Multiple Ways of Nitric Oxide Production in Plants and Its Functional Activity under Abiotic Stress Conditions.International journal of molecular sciences · 2023Review
- Transport, functions, and interaction of calcium and manganese in plant organellar compartments.Plant physiology · 2021Review
- Plant Copper Amine Oxidases: Key Players in Hormone Signaling Leading to Stress-Induced Phenotypic Plasticity.International journal of molecular sciences · 2021Review
- CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement.Journal of Zhejiang University. Science. B · 2021Review
- Chemical Structure and Biological Activity of Humic Substances Define Their Role as Plant Growth Promoters.Molecules (Basel, Switzerland) · 2021Review
- Arginine Increases Tolerance to Nitrogen Deficiency inFrontiers in plant science · 2021Article
- Nitric Oxide Alters the Pattern of Auxin Maxima and PIN-FORMED1 During Shoot Development.Frontiers in plant science · 2021Article
- Amino Acid and Carbohydrate Metabolism Are Coordinated to Maintain Energetic Balance during Drought in Sugarcane.International journal of molecular sciences · 2020Article
- Nitric Oxide Overproduction byPlants (Basel, Switzerland) · 2020Article
- Effects of nitric oxide on the GABA, polyamines, and proline in tea (Camellia sinensis) roots under cold stress.Scientific reports · 2020Article
- Fish By-Product Use as Biostimulants: An Overview of the Current State of the Art, Including Relevant Legislation and Regulations within the EU and USA.Molecules (Basel, Switzerland) · 2020Review
- The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases.Frontiers in plant science · 2020Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation of either arginase structural gene (ARGAH1 or ARGAH2 encoding arginine [Arg] amidohydrolase-1 and -2, respectively) resulted in increased formation of lateral and adventitious roots in Arabidopsis (Arabidopsis thaliana) seedlings and increased nitric oxide (NO) accumulation and efflux, detected by the fluorogenic traps 3-amino,4-aminomethyl-2',7'-difluorofluorescein diacetate and diamino-rhodamine-4M, respectively. Upon seedling exposure to the synthetic auxin naphthaleneacetic acid, NO accumulation was differentially enhanced in argah1-1 and argah2-1 compared with the wild type. In all genotypes, much 3-amino,4-aminomethyl-2',7'-difluorofluorescein diacetate fluorescence originated from mitochondria. The arginases are both localized to the mitochondrial matrix and closely related. However, their expression levels and patterns differ: ARGAH1 encoded the minor activity, and ARGAH1-driven beta-glucuronidase (GUS) was expressed throughout the seedling; the ARGAH2::GUS expression pattern was more localized. Naphthaleneacetic acid increased seedling lateral root numbers (total lateral roots per primary root) in the mutants to twice the number in the wild type, consistent with increased internal NO leading to enhanced auxin signaling in roots. In agreement, argah1-1 and argah2-1 showed increased expression of the auxin-responsive reporter DR5::GUS in root tips, emerging lateral roots, and hypocotyls. We propose that Arg, or an Arg derivative, is a potential NO source and that reduced arginase activity in the mutants results in greater conversion of Arg to NO, thereby potentiating auxin action in roots. This model is supported by supplemental Arg induction of adventitious roots and increased NO accumulation in argah1-1 and argah2-1 versus the wild type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.