ArticleApplied and environmental microbiology2008
Group 2 sigma factor SigB of Corynebacterium glutamicum positively regulates glucose metabolism under conditions of oxygen deprivation.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Regulation of oxidative stress response and antioxidant modification in Corynebacterium glutamicum.World journal of microbiology & biotechnology · 2024Review
- Overlapping SigH and SigE sigma factor regulons inFrontiers in microbiology · 2022Article
- TheMicroorganisms · 2021Article
- Coexistence of the Entner-Doudoroff and Embden-Meyerhof-Parnas pathways enhances glucose consumption of ethanol-producing Corynebacterium glutamicum.Biotechnology for biofuels · 2021Article
- Physiology and Transcriptional Analysis of (p)ppGpp-Related Regulatory Effects inFrontiers in microbiology · 2019Article
- Identifying the Growth Modulon ofFrontiers in microbiology · 2019Article
- Deciphering the Adaptation ofGenes · 2018Article
- Assignment of sigma factors of RNA polymerase to promoters in Corynebacterium glutamicum.AMB Express · 2017Article
- Deletion ofAntimicrobial agents and chemotherapy · 2017Article
- Overexpression of the primary sigma factor geneMetabolic engineering communications · 2017Article
- Enhanced Glucose Consumption and Organic Acid Production by Engineered Corynebacterium glutamicum Based on Analysis of a pfkB1 Deletion Mutant.Applied and environmental microbiology · 2017Article
- Article
- Use of In Vitro Transcription System for Analysis of Corynebacterium glutamicum Promoters Recognized by Two Sigma Factors.Current microbiology · 2016Article
- Transcriptome and Multivariable Data Analysis of Corynebacterium glutamicum under Different Dissolved Oxygen Conditions in Bioreactors.PloS one · 2016Article
- Exploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example.Frontiers in microbiology · 2015Article
- Corynebacterium glutamicum promoters: a practical approach.Microbial biotechnology · 2013Review
- Transcriptional control of the F0F1-ATP synthase operon of Corynebacterium glutamicum: SigmaH factor binds to its promoter and regulates its expression at different pH values.Microbial biotechnology · 2013Article
- Engineering of Corynebacterium glutamicum for high-yield L-valine production under oxygen deprivation conditions.Applied and environmental microbiology · 2013Article
- Article
- Overexpression of genes encoding glycolytic enzymes in Corynebacterium glutamicum enhances glucose metabolism and alanine production under oxygen deprivation conditions.Applied and environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sigB gene of Corynebacterium glutamicum encodes a group 2 sigma factor of RNA polymerase. Under conditions of oxygen deprivation, the sigB gene is upregulated and cells exhibit high productivity of organic acids as a result of an elevated glucose consumption rate. Using DNA microarray and quantitative reverse transcription-PCR (RT-PCR) analyses, we found that sigB disruption led to reduced transcript levels of genes involved in the metabolism of glucose into organic acids. This in turn resulted in retardation of glucose consumption by cells under conditions of oxygen deprivation. These results indicate that SigB is involved in positive regulation of glucose metabolism genes and enhances glucose consumption under conditions of oxygen deprivation. Moreover, sigB disruption reduced the transcript levels of genes involved in various cellular functions, including the glucose metabolism genes not only in the growth-arrested cells under conditions of oxygen deprivation but also in the cells during aerobic exponential growth, suggesting that SigB functions as another vegetative sigma factor.
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