ArticleJournal of the Royal Society, Interface2009
Control of translation initiation: a model-based analysis from limited experimental data.
Article in Journal of the Royal Society, Interface, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- Kinetic modelling reveals the presence of multistability in normal and stressful conditions in translational initiation mechanism.PloS one · 2025Article
- Modeling the ribosomal small subunit dynamic in Saccharomyces cerevisiae based on TCP-seq data.Nucleic acids research · 2022Article
- Comparing antiviral strategies against COVID-19 via multiscale within-host modelling.Royal Society open science · 2021Article
- A stochastic model for simulating ribosome kinetics in vivo.PLoS computational biology · 2020Article
- Predictive biophysical modeling and understanding of the dynamics of mRNA translation and its evolution.Nucleic acids research · 2016Article
- mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach.BMC systems biology · 2014Article
- Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview.Computational and structural biotechnology journal · 2012Review
- A systems view of the protein expression process.Systems and synthetic biology · 2011Article
- Computational modeling and analysis of insulin induced eukaryotic translation initiation.PLoS computational biology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have built a detailed kinetic model of translation initiation in yeast and have used a novel approach to determine the flux controlling steps based on limited experimental data. An efficient parameter estimation method was adapted in order to fit the most uncertain parameters (rate constants) to in vivo measurements in yeast. However, it was found that there were many other sets of plausible parameter values that also gave a good fit of the model to the data. We therefore used random sampling of this uncertain parameter space to generate a large number of diverse fitted parameter sets. A compact characterization of these parameter sets was provided by considering flux control. In particular, we suggest that the rate of translation initiation is most strongly influenced by one of two reactions: either the guanine nucleotide exchange reaction involving initiation factors eIF2 and eIF2B or the assembly of the multifactor complex from its constituent protein/tRNA containing complexes. It is hoped that the approach presented in this paper will add to our understanding of translation initiation pathway and can be used to identify key system-level properties of other biochemical processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.