Evidence map›Paper›PMID 18566944›Full record

ReviewJournal of rehabilitation research and development2008

Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategies.

Charlene E Hafer-Macko, Alice S Ryan, Frederick M Ivey, Richard F Macko

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of rehabilitation research and development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00387712 (Inflammatory Abnormalities in Muscle After Stroke), which is not on this map. Cited by 76 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 6 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00387712 nacompletednot on this map

Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2006 to 2014Enrolled99ConditionsStroke, InflammationArmsVelocity based treadmill training, Duration based treadmill training
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 6 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
  2. Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Changes in fat mass in stroke survivors: a systematic review.International journal of stroke : official journal of the International Stroke Society · 2012
    Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Strength Training for Skeletal Muscle Endurance after Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Mimicking muscle activity with electrical stimulation.Journal of neural engineering · 2011
    Trial
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charlene E Hafer-MackoDivision of Gerontology, University of Maryland School of Medicine, Baltimore, MD, USA. cmacko@grecc.umaryland.edu
Alice S Ryan
Frederick M Ivey
Richard F Macko
University of Maryland, Baltimore · US

Funding

UPPER EXTREMITY TRAINING FOR CHRONIC STROKEP60AG012583 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLDBERG, ANDREW P · 1994 to 2005
$7.8M
Diet and Exercise: Race, Postmenopause and MetabolismR01AG019310 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · 2001 to 2005
$1.5M
NIA NIH HHS P30-AG-12583NIA NIH HHS P60 AG012583NIA NIH HHS R01 AG019310NIA NIH HHS R01-AG-019310
6 · The paper itself

Abstract

Stroke is the leading cause of disability in the United States. New evidence reveals significant structural and metabolic changes in skeletal muscle after stroke. Muscle alterations include gross atrophy and shift to fast myosin heavy chain in the hemiparetic (contralateral) leg muscle; both are related to gait deficit severity. The underlying molecular mechanisms of this atrophy and muscle phenotype shift are not known. Inflammatory markers are also present in contralateral leg muscle after stroke. Individuals with stroke have a high prevalence of insulin resistance and diabetes. Skeletal muscle is a major site for insulin-glucose metabolism. Increasing evidence suggests that inflammatory pathway activation and oxidative injury could lead to wasting, altered function, and impaired insulin action in skeletal muscle. The health benefits of exercise in disabled populations have now been recognized. Aerobic exercise improves fitness, strength, and ambulatory performance in subjects with chronic stroke. Therapeutic exercise may modify or reverse skeletal muscle abnormalities.

Indexed as

Recovery of FunctionStroke RehabilitationAnimalsBlood GlucoseBody CompositionExercise TherapyHemiplegiaHumansInsulinLower ExtremityMuscle, SkeletalMuscular AtrophyMyosin Heavy ChainsSpinal Cord InjuriesStrokeWalkingBlood GlucoseInsulinMyosin Heavy Chains

Identifiers

PMID18566944
PMCPMC2978978
OpenAlexW2044169284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.