ArticleParasitology research2008
Leishmania lysosomal targeting signal is recognized by yeast and not by mammalian cells.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Leishmaniasis, caused by Leishmania parasites, is an important public health problem worldwide. Leishmania, like other trypanosomatids, present unique biological features as compared to higher eukaryotes that can be exploited with the intent of finding new chemotherapeutical/vaccine candidates. Mechanisms of cellular sorting in Leishmania can be viewed as such potential targets. We have previously demonstrated a role for the pro-domain of a Leishmania cysteine proteinase in lysosomal targeting. In this paper, we show that this signal is not recognized by mammalian cells and is recognized by yeast; we also discuss here the implications of these findings related to evolution and further characterization of the Leishmania trafficking machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.