ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2008
The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 56 citations in OpenAlex.
- Toward Nutrient-Rich Rice: Biofortification through Mineral Accumulation and Low Phytic Acid Content.Journal of agricultural and food chemistry · 2025Article
- Identification of a novel mutation in theFrontiers in plant science · 2024Article
- Article
- Expression regulation of myo-inositol 3-phosphate synthase 1 (INO1) in determination of phytic acid accumulation in rice grain.Scientific reports · 2019Article
- Novel allelic variant of Lpa1 gene associated with a significant reduction in seed phytic acid content in rice (Oryza sativa L.).PloS one · 2019Article
- Locating QTLs controlling overwintering seedling rate in perennial glutinous rice 89-1 (Oryza sativa L.).Genes & genomics · 2018Article
- Manipulating the Phytic Acid Content of Rice Grain Toward Improving Micronutrient Bioavailability.Rice (New York, N.Y.) · 2018Review
- Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism.BMC genomics · 2016Article
- Tissue-specific expression, developmentally and spatially regulated alternative splicing, and protein subcellular localization of OsLpa rice.Journal of Zhejiang University. Science. B · 2016Article
- Seed Biofortification and Phytic Acid Reduction: A Conflict of Interest for the Plant?Plants (Basel, Switzerland) · 2015Review
- Overexpression of a Gene Involved in Phytic Acid Biosynthesis Substantially Increases Phytic Acid and Total Phosphorus in Rice Seeds.Plants (Basel, Switzerland) · 2015Article
- Seed-specific silencing of OsMRP5 reduces seed phytic acid and weight in rice.Transgenic research · 2014Article
- Characterization of OsMIK in a rice mutant with reduced phytate content reveals an insertion of a rearranged retrotransposon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Identification and characterization of the soybean IPK1 ortholog of a low phytic acid mutant reveals an exon-excluding splice-site mutation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Identification of genes necessary for wild-type levels of seed phytic acid in Arabidopsis thaliana using a reverse genetics approach.Molecular genetics and genomics : MGG · 2011Article
- A nonsense mutation in a putative sulphate transporter gene results in low phytic acid in barley.Functional & integrative genomics · 2011Article
- Article
- Mutations of the multi-drug resistance-associated protein ABC transporter gene 5 result in reduction of phytic acid in rice seeds.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rice low phytic acid 1 (lpa1) mutant was originally identified using a forward genetics approach. This mutant exhibits a 45% reduction in rice seed phytic acid with a molar-equivalent increase in inorganic phosphorus; however, it does not appear to differ significantly in productivity from its wild-type progenitor. A second lpa1 mutant was identified from additional screening for high seed inorganic phosphorus phenotypes. Using a positional cloning strategy, we identified a single candidate gene at the rice Lpa1 locus. Sequence analysis of the candidate gene from the lpa1 mutants revealed two independent mutations (a single base pair substitution and a single base pair deletion) that confirmed the identification of this candidate as the rice low phytic acid 1 gene, OsLpa1. The OsLpa1 gene has three splice variants. The location and nature of the two mutations suggests that these lesions only affect the translation of the predicted protein derived from the longest transcript. The proteins encoded by OsLpa1 do not have homology to any of the inositol phosphate metabolism genes recently characterized in plants, although there is homology to 2-phosphoglycerate kinase, an enzyme found in hyperthermophilic methanogens that catalyzes the formation of 2,3-bisphosphoglycerate from 2-phosphoglycerate. OsLpa1 represents a novel gene involved in phytic acid metabolism.
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