ReviewInternational journal of biological sciences2008
The role of erythropoietin as an inhibitor of tissue ischemia.
Review in International journal of biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Erythropoietin Attenuates Insulin Resistance and Renal Inflammation in High-Sucrose-Treated Rats.International journal of molecular sciences · 2025Article
- Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway.Scientific reports · 2023Article
- Erythropoietin Suppresses the Hepatic Fibrosis Caused by Thioacetamide: Role of the PI3K/Akt and TLR4 Signaling Pathways.Oxidative medicine and cellular longevity · 2023Article
- Effects of Iron Sucrose and Erythropoietin on Transfusion Requirements in Patients with Preoperative Iron Deficiency Anemia Undergoing on-Pump Coronary Artery Bypass Graft.The journal of Tehran Heart Center · 2022Article
- PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome.Health physics · 2018Article
- Histopathological study of erythropoietin protective effect on carbon monoxide-induced cardiotoxicity in rat.Iranian journal of basic medical sciences · 2017Article
- Erythropoietin and sildenafil protect against ischemia/reperfusion injury following testicular torsion in adult rats.Experimental and therapeutic medicine · 2017Article
- Effect of SDF-1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury.International journal of molecular medicine · 2015Article
- Hepatocellular heme oxygenase-1: a potential mechanism of erythropoietin-mediated protection after liver ischemia-reperfusion injury.Shock (Augusta, Ga.) · 2014Article
- Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.International urology and nephrology · 2014Article
- Echocardiographic Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing Ischemia-Reperfusion Injuries during Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study.Iranian journal of medical sciences · 2014Article
- The effect of erythropoietin on ischemia/reperfusion injury after testicular torsion/detorsion: a randomized experimental study.ISRN urology · 2013Article
- Effects of erythropoietin on electrocardiogram changes in carbon monoxide poisoning: an experimental study in rats.Iranian journal of pharmaceutical research : IJPR · 2012Article
- Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells.Epigenetics · 2010Article
- Intestinal hormones and growth factors: effects on the small intestine.World journal of gastroenterology · 2009Review
- Erythropoietin Pretreatment Effect on Blood Glucose and Its Relationship With Inflammatory Factors After Brain Ischemic-Reperfusion Injury in Rats.Basic and clinical neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythropoietin is a hypoxia-induced cytokine that stimulates erythropoiesis through the promotion of erythroid precursor cell proliferation and differentiation. Recent evidence supports that erythropoietin has a broad spectrum of tissue protecting actions affecting other systems than hemopoietic. Lately, research has focused on the nonhemopoietic effects of erythropoietin against tissue ischemia due to the unexpected observations of erythropoietin receptor expression by various cells, such as endothelial cells, neuronal cells, cardiac myocytes, and vascular smooth muscle cells. It has been shown that erythropoietin exerts its cardioprotective action during cardiac ischemic injury through reducing the infract size and enhancing new vessel formation over a longer time frame. Erythropoietin plays a crucial role in neuroprotection in many types of ischemic injury in the central and the peripheral nervous system. It is also strongly believed that erythropoietin exhibits a critical role in many other disorders that are pathogenetically related to acute tissue ischemia. This article reviews the proposed implications of erythropoietin in tissue ischemia and discusses the possible mechanisms for this action along with its potential therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.