ArticlePPAR research2008
A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer.
Article in PPAR research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review).International journal of molecular medicine · 2026Review
- Uncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models.Archives of toxicology · 2024Article
- Effects of Electrolyte Multivitamins and Neomycin on Immunity and Intestinal Barrier Function in Transported Lambs.Animals : an open access journal from MDPI · 2024Article
- TDAG51 deficiency attenuates dextran sulfate sodium-induced colitis in mice.Scientific reports · 2022Article
- Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases.Aging and disease · 2022Article
- Regulation of Free Fatty Acid Receptor 4 on Inflammatory Gene Induced by LPS in Large Yellow Croaker (Frontiers in immunology · 2021Article
- Induced Ketosis as a Treatment for Neuroprogressive Disorders: Food for Thought?The international journal of neuropsychopharmacology · 2020Review
- Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression.Medical microbiology and immunology · 2019Article
- The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism.Molecules (Basel, Switzerland) · 2019Article
- The paramount role of cytokines and chemokines in papillary thyroid cancer: a review and experimental results.Immunologic research · 2018Review
- Epidermal PPARγ influences subcutaneous tumor growth and acts through TNF-α to regulate contact hypersensitivity and the acute photoresponse.Oncotarget · 2017Article
- Oyster crude polysaccharides attenuates lipopolysaccharide-induced cytokines production and PPARγ expression in weanling piglets.SpringerPlus · 2016Article
- Prognostic role of PPAR-γ and PTEN in the renal cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.BioMed research international · 2015Article
- Retracted: A Role for PPAR γ in the Regulation of Cytokines in Immune Cells and Cancer.PPAR research · 2015Article
- Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study.PLoS computational biology · 2014Article
- Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo.PPAR research · 2011Article
- Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.PPAR research · 2010Article
- Peroxisome proliferator-activated receptor (PPAR): balance for survival in parasitic infections.Journal of biomedicine & biotechnology · 2010Review
- Metabolic syndrome and cancer.Metabolic syndrome and related disorders · 2009Review
Corrections and comments
- Retraction · 2015-02-02Duplication of Text · Euphemisms for Duplication · Euphemisms for Plagiarism · Plagiarism of Text · · See also: https://pubpeer.com/publications/5703EADF09E4A39733685AC0241BBA
- Retracted
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARgamma and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARgamma on metabolism and cellular differentiation, abundant evidence suggests that PPARgamma is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARgamma in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.