ArticleMediators of inflammation2008
Prolonged classical NF-kappaB activation prevents autophagy upon E. coli stimulation in vitro: a potential resolving mechanism of inflammation.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Review
- Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health.Nutrients · 2021Review
- Induction of autophagy protects human dental pulp cells from lipopolysaccharide-induced pyroptotic cell death.Experimental and therapeutic medicine · 2020Article
- Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria.Frontiers in immunology · 2019Article
- Mechanism and medical implications of mammalian autophagy.Nature reviews. Molecular cell biology · 2018Review
- Autophagy dysfunction in autoinflammatory diseases.Journal of autoimmunity · 2018Review
- NF-κB Signalling in Glioblastoma.Biomedicines · 2017Review
- Phycocyanin: A Potential Drug for Cancer Treatment.Journal of Cancer · 2017Review
- The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis.Cell death discovery · 2017Article
- Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis.World journal of gastroenterology · 2016Article
- Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy.Scientific reports · 2016Article
- Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.Scientific reports · 2016Article
- AcanthopanaxMediators of inflammation · 2016Article
- Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis.Journal of neuroinflammation · 2015Article
- Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.International journal of molecular sciences · 2014Review
- Pathogen-induced autophagy signaling in innate immunity.Journal of innate immunity · 2013Review
- Mapping autophagy on to your metabolic radar.Diabetes · 2012Review
- Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process.International journal of cell biology · 2012Article
- TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.PloS one · 2012Article
- Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection.Discovery medicine · 2011Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of NF-kappaB is known to prevent apoptosis but may also act as proapoptotic factor in order to eliminate inflammatory cells. Here, we show that classical NF-kappaB activation in RAW 264.7 and bone marrow-derived macrophages upon short E. coli coculture is necessary to promote cell death at late time points. At 48 hours subsequent to short-term, E. coli challenge increased survival of NF-kappaB-suppressed macrophages was associated with pattern of autophagy whereas macrophages with normal NF-kappaB signalling die. Cell death of normal macrophages was indicated by preceding downregulation of autophagy associated genes atg5 and beclin1. Restimulation of macrophages with LPS at 48 hours after E. coli treatment results in augmented proinflammatory cytokine production in NF-kappaB-suppressed macrophages compared to control cells. We thus demonstrate that classical NF-kappaB activation inhibits autophagy and promotes delayed programmed cell death. This mechanism is likely to prevent the recovery of inflammatory cells and thus contributes to the resolution of inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.