ArticleCell death and differentiation2008
Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.
Article in Cell death and differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice.bioRxiv : the preprint server for biology · 2026Article
- The IAP family member BRUCE/BIRC6: an emerging new player in balancing life and death.Apoptosis : an international journal on programmed cell death · 2026Review
- Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity.Scientific reports · 2023Article
- Fusion of Normoxic- and Hypoxic-Preconditioned Myoblasts Leads to Increased Hypertrophy.Cells · 2022Article
- Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue.Scientific reports · 2020Article
- Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways.International journal of molecular sciences · 2019Article
- Reduced prostaglandin IFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.Cell cycle (Georgetown, Tex.) · 2015Article
- The skeletal muscle arachidonic acid cascade in health and inflammatory disease.Nature reviews. Rheumatology · 2014Review
- Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation.Cell communication and signaling : CCS · 2014Article
- Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Inhibition of caspase mediated apoptosis restores muscle function after crush injury in rat skeletal muscle.Apoptosis : an international journal on programmed cell death · 2012Article
- Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts.PloS one · 2009Article
- Prostaglandins in muscle regeneration.Journal of muscle research and cell motility · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During skeletal muscle growth and regeneration, the majority of differentiating myoblasts undergoes cell-cell fusion to form multinucleated myofibers, whereas a proportion of myoblasts undergoes apoptosis. The treatment of myoblasts with prostaglandin F2alpha (PGF2alpha) during myogenesis in vitro leads to the formation of large myotubes, but the mechanism by which PGF2alpha promotes myotube growth has not been investigated. Here, we demonstrate that PGF2alpha reduces cell death during myogenesis in vitro and in vivo. In addition, we show that PGF2alpha increases expression of the inhibitor of apoptosis protein (IAP) BRUCE through a pathway dependent on the nuclear factor of activated T cell 2 transcription factor. Importantly, PGF2alpha-mediated reduction in muscle cell death is dependent on BRUCE, and overexpression of BRUCE is sufficient to promote muscle cell survival and growth. These results establish a previously unrecognized link between NFAT signaling and regulation of IAP expression and are the first to identify a signaling pathway that increases BRUCE expression. In addition, our results provide evidence that increasing the pool of muscle cells available for fusion by inhibiting cell death enhances myotube growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.