ArticleJournal of immunology (Baltimore, Md. : 1950)2008
CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 122 citations in OpenAlex.
- Cerebrospinal fluid cytokine-driven immune responses in HIV-negative cryptococcal meningitis.Frontiers in medicine · 2026Article
- Time-resolved multi-omics reveals macrophage-centered immunometabolic remodeling in cutaneous dematiaceous fungal infection.Frontiers in immunology · 2026Article
- Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea.Allergy, asthma & immunology research · 2025Article
- MAIT cells protect against sterile lung injury.Cell reports · 2025Article
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- Dendritic Cells: Multifunctional Roles in Host Defenses toJournal of fungi (Basel, Switzerland) · 2023Review
- CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.Cell death & disease · 2023Article
- LPS binding protein and activation signatures are upregulated during asthma exacerbations in children.Respiratory research · 2023Article
- Innate Pulmonary Phagocytes and Their Interactions with PathogenicJournal of fungi (Basel, Switzerland) · 2023Review
- Alternatively activated lung alveolar and interstitial macrophages promote fungal growth.iScience · 2023Article
- Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
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- Review
- Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis.The American journal of pathology · 2022Article
- Microbial Metabolites in the Maturation and Activation of Dendritic Cells and Their Relevance for Respiratory Immunity.Frontiers in immunology · 2022Review
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- Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal PathogenFrontiers in immunology · 2021Article
- Immune Modulation of Allergic Asthma by Early Pharmacological Inhibition of RIP2.ImmunoHorizons · 2020Article
- The Diverse Roles of Monocytes in Cryptococcosis.Journal of fungi (Basel, Switzerland) · 2020Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires the development of T1-type immunity. CCR2-deficient mice infected with C. neoformans develop a non-protective T2 immune response and persistent infection. The mechanisms responsible for this aberrant response are unknown. The objective of this study was to define the number, phenotype, and microanatomic location of dendritic cells (DC) residing within the lung of CCR2+/+ or CCR2-/- mice throughout a time course following infection with C. neoformans. Results demonstrate the CCR2-mediated recruitment of conventional DC expressing modest amounts of costimulatory molecules. DC recruitment was preceded by the up-regulation in the lung of the CCR2 ligands CCL2 and CCL7. Colocalization of numerous DC and CD4+ T cells within bronchovascular infiltrates coincided with increased expression of IL-12 and IFN-gamma. By contrast, in the absence of CCR2, DC recruitment was markedly impaired, bronchovascular infiltrates were diminished, and mice developed features of T2 responses, including bronchovascular collagen deposition and IL-4 production. Our results demonstrate that CCR2 is required for the recruitment of large numbers of conventional DC to bronchovascular infiltrates in mice mounting a T1 immune response against a fungal pathogen. These findings shed new insight into the mechanism(s) by which DC recruitment alters T cell polarization in response to an infectious challenge within the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.