ArticleJournal of immunology (Baltimore, Md. : 1950)2008
MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Chelidonic acid amelioratesFrontiers in immunology · 2026Article
- Identification and Pathogenicity ofMicroorganisms · 2025Article
- Immunity to pathogenic fungi in the eye.Seminars in immunology · 2023Review
- Innate Immune System Activation, Inflammation and Corneal Wound Healing.International journal of molecular sciences · 2022Review
- Defence response in plants and animals against a common fungal pathogenCurrent research in microbial sciences · 2022Review
- Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections - the role of neutrophils in fungal killing, tissue damage and cytokine production.Current opinion in microbiology · 2021Review
- Extracellular Matrix Deposition and Remodeling after Corneal Alkali Burn in Mice.International journal of molecular sciences · 2021Article
- Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq.Investigative ophthalmology & visual science · 2020Article
- Structural basis of Fusarium myosin I inhibition by phenamacril.PLoS pathogens · 2020Article
- Analysis of differentially expressed genes in bacterial and fungal keratitis.Indian journal of ophthalmology · 2020Article
- Commentary: Analysis of differentially expressed genes in bacterial and fungal keratitis.Indian journal of ophthalmology · 2020Article
- Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.European journal of immunology · 2019Article
- Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β inJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis.Investigative ophthalmology & visual science · 2018Article
- Protein Deiminase 4 and CR3 RegulateFrontiers in immunology · 2018Article
- Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani.Investigative ophthalmology & visual science · 2017Article
- Role of MyD88 in adenovirus keratitis.Immunology and cell biology · 2017Article
- JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.Journal of leukocyte biology · 2016Article
- Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Pattern recognition receptors in microbial keratitis.Eye (London, England) · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The fungal pathogens Fusarium solani and Fusarium oxysporum cause severe corneal disease in the United States and worldwide and were the causative organisms in a recent outbreak of contact lens-associated keratitis. To characterize innate immunity in Fusarium keratitis, we developed a murine model in which conidia are injected into the corneal stroma. Immunocompetent C57BL/6 mice rapidly developed severe corneal opacification associated with neutrophil infiltration and clearance of Fusarium hyphae. In contrast, neutrophil infiltration was delayed in MyD88-/- mice, resulting in uncontrolled growth of Fusarium hyphae in the corneal stroma and anterior chamber, and eventually resulting in corneal perforation. Corneal opacification scores in TLR2-/-, TLR4-/-, and TLR2/4-/- mice were similar to those of C57BL/6 mice; however, TLR4-/- and TLR2/4-/- mice had impaired antifungal responses. The phenotype of infected IL-1R1-/- mice was similar to that of MyD88-/- mice, with uncontrolled fungal growth resulting in corneal perforation. IL-1R1-/- mice also produced significantly less CXCL1/KC in the corneal stroma compared with C57BL/6 mice consistent with delayed neutrophil recruitment to the corneal stroma. Together, these findings indicate that IL-1R1 and MyD88 regulate CXC chemokine production and neutrophil recruitment to the cornea, and that TLR4 has an important role in controlling growth and replication of these pathogenic fungi.
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