ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives.Frontiers in immunology · 2021Review
- B cells as antigen-presenting cells in transplantation rejection and tolerance.Cellular immunology · 2020Review
- The pursuit of transplantation tolerance: new mechanistic insights.Cellular & molecular immunology · 2019Article
- Old game, new players: Linking classical theories to new trends in transplant immunology.World journal of transplantation · 2017Review
- Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.Current opinion in organ transplantation · 2015Review
- B cells with immune-regulating function in transplantation.Nature reviews. Nephrology · 2014Review
- Transplantation tolerance and its outcome during infections and inflammation.Immunological reviews · 2014Review
- Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Article
- Induction of tolerance through mixed chimerism.Cold Spring Harbor perspectives in medicine · 2014Review
- Experimental models of B cell tolerance in transplantation.Seminars in immunology · 2012Review
- Immuno-intervention for the induction of transplantation tolerance through mixed chimerism.Seminars in immunology · 2011Review
- Article
- Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells.Frontiers in immunology · 2011Article
- Transplantation tolerance through mixed chimerism.Nature reviews. Nephrology · 2010Review
- Article
- Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010Article
- Mechanisms of transplantation tolerance in animals and humans.Transplantation · 2009Article
- CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.Blood · 2009Article
- Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials.Transplantation · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Allogeneic bone marrow chimerism induces robust systemic tolerance to donor alloantigens. Achievement of chimerism requires avoidance of marrow rejection by pre-existing CD4 and CD8 T cells, either of which can reject fully MHC-mismatched marrow. Both barriers are overcome with a minimal regimen involving anti-CD154 and low dose (3 Gy) total body irradiation, allowing achievement of mixed chimerism and tolerance in mice. CD4 cells are required to prevent marrow rejection by CD8 cells via a novel pathway, wherein recipient CD4 cells interacting with recipient class II MHC tolerize directly alloreactive CD8 cells. We demonstrate a critical role for recipient MHC class II, B cells, and dendritic cells in a pathway culminating in deletional tolerance of peripheral alloreactive CD8 cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.